Figure 7

Higher order network of interactions among EGF-regulated genes. Network of genomic interactions among EGF-regulated pathways (Holm-adjusted p-value < 0.01) as defined by GlobalAncova using KEGG database functional annotation. Nodes (pathways) that have at least two regulated genes (as defined by RankProd analysis) in common with other pathways are connected by continuous lines to these other pathways. The strength of each pathway interconnection (i.e. the number of shared regulated genes) is expressed by the width of the continuous lines connecting the two nodes. The node color indicates the interconnectivity of the nodes ranging from no connection to any other pathway (white) to many connections with other pathways (red). Numbers define KEGG categories as listed in Table 3.