Table 3 Functional analysis of EGF responsive pathways.
| Â | ID | name | genes | regulated genes | connections |
|---|---|---|---|---|---|
1 | 05200 | Pathways in cancer | 265 | 31 | 139 |
2 | 04510 | Focal adhesion | 156 | 17 | 97 |
3 | 04660 | T cell receptor signaling pathway | 80 | 7 | 69 |
4 | 05215 | Prostate cancer | 74 | 7 | 65 |
5 | 04662 | B cell receptor signaling pathway | 59 | 6 | 63 |
6 | 04010 | MAPK signaling pathway | 203 | 25 | 62 |
7 | 05210 | Colorectal cancer | 55 | 6 | 61 |
8 | 05222 | Small cell lung cancer | 76 | 12 | 60 |
9 | 04012 | ErbB signaling pathway | 74 | 9 | 60 |
10 | 04722 | Neurotrophin signaling pathway | 104 | 9 | 60 |
11 | 05220 | Chronic myeloid leukemia | 64 | 7 | 59 |
12 | 04810 | Regulation of actin cytoskeleton | 163 | 14 | 46 |
13 | 05214 | Glioma | 55 | 5 | 44 |
14 | 05211 | Renal cell carcinoma | 58 | 9 | 44 |
15 | 05223 | Non-small cell lung cancer | 51 | 6 | 42 |
16 | 05142 | Chagas disease | 71 | 5 | 41 |
17 | 04310 | Wnt signaling pathway | 118 | 7 | 41 |
18 | 05219 | Bladder cancer | 35 | 5 | 37 |
19 | 05140 | Leishmaniasis | 42 | 4 | 36 |
20 | 04620 | Toll-like receptor signaling pathway | 59 | 4 | 36 |
21 | 04912 | GnRH signaling pathway | 70 | 6 | 35 |
22 | 04210 | Apoptosis | 74 | 8 | 32 |
23 | 04916 | Melanogenesis | 76 | 3 | 30 |
24 | 04630 | Jak-STAT signaling pathway | 94 | 12 | 27 |
25 | 05410 | Hypertrophic cardiomyopathy (HCM) | 60 | 7 | 27 |
26 | 05414 | Dilated cardiomyopathy | 65 | 7 | 27 |
27 | 04115 | p53 signaling pathway | 58 | 11 | 25 |
28 | 04621 | NOD-like receptor signaling pathway | 40 | 6 | 25 |
29 | 05412 | Arrythmogenic right ventricular cardiomyopathy (ARVC) | 52 | 6 | 25 |
30 | 04920 | Adipocytokine signaling pathway | 55 | 6 | 24 |
31 | 04120 | Ubiquitin mediated proteolysis | 120 | 15 | 22 |
32 | 04370 | VEGF signaling pathway | 57 | 3 | 21 |
33 | 04060 | Cytokine-cytokine receptor interaction | 132 | 14 | 18 |
34 | 04640 | Hematopoietic cell lineage | 43 | 7 | 16 |
35 | 04530 | Tight junction | 97 | 7 | 16 |
36 | 04340 | Hedgehog signaling pathway | 39 | 3 | 15 |
37 | 04622 | RIG-I-like receptor signaling pathway | 46 | 4 | 15 |
38 | 04360 | Axon guidance | 105 | 9 | 14 |
39 | 05217 | Basal cell carcinoma | 41 | 1 | 12 |
40 | 04144 | Endocytosis | 162 | 13 | 11 |
41 | 05014 | Amyotrophic lateral sclerosis (ALS) | 41 | 3 | 8 |
42 | 04350 | TGF-beta signaling pathway | 69 | 6 | 6 |
43 | 00561 | Glycerolipid metabolism | 38 | 4 | 5 |
44 | 00564 | Glycerophospholipid metabolism | 59 | 4 | 5 |
45 | 00600 | Sphingolipid metabolism | 27 | 4 | 4 |
46 | 04070 | Phosphatidylinositol signaling system | 66 | 4 | 4 |
47 | 00562 | Inositol phosphate metabolism | 50 | 3 | 3 |
48 | 00565 | Ether lipid metabolism | 20 | 1 | 3 |
49 | 05020 | Prion diseases | 22 | 3 | 3 |
50 | 04710 | Circadian rhythm - mammal | 20 | 4 | 2 |
51 | 00601 | Glycosphingolipid biosysnthesis - lacto and neolacto series | 21 | 2 | 0 |
52 | 00532 | Glycosaminoglycan biosynthesis - chondroitin sulphate | 17 | 2 | 0 |
53 | 00760 | Nicotinate and nicotinamide metabolism | 17 | 4 | 0 |
54 | 00750 | Vitamin B6 metabolism | 5 | 1 | 0 |
55 | 00790 | Folate biosynthesis | 9 | 0 | 0 |