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Table 2 A summary of gene expression changes induced by BaP in MCF7 cells using microarray and RT-PCR analysis

From: Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene

   Change in G1 Change in S Change in G2/M
Gene Symbol Biological function RT-PCR Microarrays RT-PCR Microarrays RT-PCR Microarrays
CYP1A1 Xenobiotic metabolism ↑ 91.5-fold ↑ 1866.8-fold ↑ 73.7-fold
CYP1B1 Xenobiotic metabolism ↑ 19-fold ↑ 2.7-fold ↑ 40.4-fold ↑ 3.2-fold ↑ 21.9-fold ↑ 2.3-fold
GDF15 Cell differentiation ↑ 11.2-fold ↑ 22.5-fold ↑ 8.9-fold ↑ 2-fold
TIPARP PARP family ↑ 5.5-fold ↑ 5.8-fold ↑ 2.9-fold ↑ 6-fold ↑ 4.7-fold
JUN Cell proliferation ↑ 5.5-fold ↑ 1.8-fold ↑ 5.1-fold ↑ 3.6-fold
p21 cell cycle checkpoints ↑ 3.2-fold ↑ 6.6-fold
RASAL1 Ras regulator ↑ 3.4-fold ↑ 2.8-fold ↑ 3.3-fold ↓ 2.8-fold
RGC32 Cell cycle control ↑ 2.9-fold ↑ 1.6-fold ↑ 2.3-fold ↑ 2.3-fold ↑ 1.5-fold
ALDH1A3 Xenobiotic metabolism ↑ 1.7-fold ↑ 4.2-fold ↑ 4.3-fold ↑ 2.4-fold
DLX2 Development ↑ 1.5-fold ↑ 4.8-fold ↑ 5-fold ↑ 2.5-fold ↑ 3.3-fold
CEBPA Mitotic growth arrest ↑ 1.7-fold ↑ 1.5-fold ↑ 1.7-fold
NRF2 Oxidative stress ↑ 1.5-fold ↑ 1.6-fold ↑ 1.6-fold
ATF3 Transcription Factor ↑ 3-fold ↑ 6.1-fold ↑ 4.5-fold  
DNAJB4 Oxidative stress ↑ 2.2-fold ↑ 1.6-fold ↑ 1.9-fold ↑ 1.5-fold
Bax Apoptosis ↑ 1.5-fold ↑ 1.6-fold ↑ 1.6-fold
SPRY4 MAPK signalling ↑ 4.5-fold ↑ 1.7-fold
GSTT2 Xenobiotic metabolism ↑ 2.8-fold ↑ 1.7-fold
CABLES2 Apoptosis ↑ 2.3-fold
PTGER4 T-cell factor signalling ↑ 2.7-fold ↑ 1.5-fold ↑ 2.2-fold
BBC3 Apoptosis ↑ 2.1-fold ↑ 5-fold ↑ 1.9-fold
EGR1 Cell growth and proliferation ↑ 6.7-fold ↑ 2.7-fold ↑ 2.5-fold
CTNNB1 Cell adhesion ↑ 1.5-fold ↑ 2.25-fold
PLK3 Cell cycle control ↑ 2.5-fold ↑ 3.4-fold
AFF4 Transcription Elongation ↓ 2.6-fold ↓ 1.5-fold ↓ 6.2-fold
ZBRK1 DNA damage response ↓ 4.7-fold
DKK1 Wnt/Catenin ↓ 7-fold ↓ 3.1-fold ↓ 2.8-fold ↓ 2.4-fold
KAT2B Transcription regulation ↓ 4.6-fold ↓ 3-fold ↓ 6.5-fold ↓ 1.7-fold
RASGRP1 Ras signalling ↓ 3.8-fold ↓ 1.5-fold ↓ 2.2-fold ↓ 6-fold ↓ 2-fold
JMJD2C Histone demethylase ↓ 3.6-fold ↓ 4.5-fold ↓ 2-fold ↓ 3-fold ↓ 1.8-fold
HDAC4 Cell cycle control ↓ 2.1-fold ↓ 2.7-fold ↓ 1.8-fold ↓ 1.8-fold
FERMT1 Actin cytoskeleton ↓ 2.1-fold ↓ 6.7-fold ↓ 1.8-fold ↓ 2.5-fold
Scaper cell cycle checkpoints ↓ 1.8-fold ↓ 1.5-fold ↓ 1.8-fold ↓ 2-fold ↓ 2.8-fold ↓ 2.2-fold
NPM1 Cell proliferation/Apoptosis ↑ 2.4-fold
YWHAQ Cell cycle control/Apoptosis
AHR Xenobiotic Metabolism
p53 Tumour Suppressor
RFC5 Replication Factor ↑ 1.8-fold
Hint1 Apoptosis ↑ 2.2-fold ↑ 1.5-fold
NQO1 Xenobiotic metabolism ↑ 2.2-fold
  1. A 1.5-fold cut-off was used. ↑ denotes up-regulation, and ↓ denotes down-regulation.