Figure 2

Genes with overall sex differential expression and their chromosome distribution. (A) Dot plot showing comparison of gene expression in female and male. Genes with significantly higher expression in male (blue), upstream of tra (light blue) or downstream of tra (dark blue) are indicated. Genes with significantly higher expression in female (red), upstream of tra (light red) or downstream of tra (dark red). Yellow dots indicate genes with expression in only female or male genotype. (B) Bar plot showing chromosomal enrichment of genes with female-biased (red), female-biased expression upstream of tra (light red), female-biased expression downstream of tra (dark red), male-biased expression (blue), male-biased expression upstream of tra (light blue), and male-biased expression downstream of tra (dark blue). Asterisks indicate significant over- or under-enrichment at three different significance levels (P < 0.05, 0.01 and 0.001 are indicated by *, **, and ***, respectively). (C) Distribution of genes with female-biased (red), or male-biased (blue) expression, within DCC-bound regions (black), or expressed genes among any genotype (gray) along the × chromosome are shown. The DCC-bound regions include those found by ChIP-Chip and ChIP-seq studies [40, 41].