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Table 2 Number of B. cenocepacia genes with a >2-fold change in expression

From: Spontaneous and evolutionary changes in the antibiotic resistance of Burkholderia cenocepacia observed by global gene expression analysis

B. cenocepacia strain and growth condition Number of genes significantly altered
in expression (>2 fold):
Exposure of J2315 to sub-MIC antimicrobials: Up-regulated Down-regulated Total
J2315 wt + 50 mg/L AMK 17 2 19
J2315 wt + 2 mg/L MEM 53 6 59
J2315 wt + 10/50 mg/L TMP/SMX 39 17 56
J2315 wt + 0.05 mM CPZ 13 5 18
J2315 wt + 0.05 mM CPZ + 50 mg/L AMK 19 16 35
J2315 resistant mutants:    
J2315-A 26 28 54a
J2315-A + 50 mg/L AMK 32 50 82a
J2315-A + 250 mg/L AMK 37 38 75a
J2315-M 39 59 98a
J2315-M + 2 mg/L MEM 67 24 83a
J2315-M + 8 mg/L MEM 39 74 113a
J2315-T 41 39 80a
J2315-T + 10/50 mg/L TMP/SMX 44 38 82a
J2315-T + 60/300 mg/L TMP/SMX 52 53 105a
ST28 outbreak isolates:    
BCC1616 89 166 255
BCC1617 83 115 198
  1. a The number of genes differentially expressed were significantly different (p < 0.001; one-way analysis of variance with square root transformation) in the resistant mutants compared to the corresponding condition of J2315 exposed to each respective antibiotic.