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Table 1 Prediction Signature

From: A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests

Gene Title Gene Symbol Entrez Gene ID Affymetrix HuGene 1.0 ST ID Validation Call frequency (%)
4-aminobutyrate aminotransferase ABAT 18 7993126 30
abhydrolase domain containing 5 ABHD5 51099 8079153 85
alkaline ceramidase 2 ACER2 340485 8154563 95
ATP citrate lyase ACLY 47 8015460 85
actin-related protein 10 homolog (S. cerevisiae) ACTR10 55860 7974587 75
ADAM metallopeptidase domain 20 ADAM20 8748 7979927 35
aldehyde dehydrogenase 18 fam., member A1 ALDH18A1 5832 7935230 75
aldehyde dehydrogenase 1 fam., member B1 ALDH1B1 219 8155327 70
anaphase promoting complex subunit 1 ANAPC1 64682 8043349 55
anaphase promoting complex subunit 5 ANAPC5 51433 7967149 25
ankyrin repeat, fam. A (RFXANK-like), 2 ANKRA2 57763 8112596 100
ADP-ribosylation factor GTPase activating protein 3 ARFGAP3 26286 8076515 55
Rho GTPase activating protein 9 ARHGAP9 64333 7964436 75
ankyrin repeat and SOCS box-containing 7 ASB7 140460 7986433 65
ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d1//ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d1 ATP6V0D1//ATP6V0D1 9114//9114 8002041 10
ATPase, H+ transporting, lysosomal 9 kDa, V0 subunit e1 ATP6V0E1 8992 8110022 75
ATPase, H+ transporting, lysosomal 50/57 kDa, V1 subunit H ATP6V1H 51606 8150797 100
B-cell CLL/lymphoma 7A BCL7A 605 7959354 85
bridging integrator 2 BIN2 51411 7963289 80
bleomycin hydrolase BLMH 642 8014008 15
brix domain containing 1//ribosome production factor 2 homolog (S. cerevisiae) BXDC1//RPF2 84154//84154 8062211 40
chromosome 11 open reading frame 61 C11orf61 79684 7952445 55
chromosome 11 open reading frame 67//integrator complex subunit 4 C11orf67//INTS4 28971//92105 7942783 50
chromosome 12 open reading frame 57 C12orf57 113246 7953564 40
chromosome 13 open reading frame 18 C13orf18 80183 7971486 50
chromosome 15 open reading frame 24 C15orf24 56851 7987172 50
chromosome 19 open reading frame 46//alkB, alkylation repair homolog 6 (E. coli) C19orf46//ALKBH6 163183//84964 8036242 30
chromosome 19 open reading frame 54 C19orf54 284325 8036956 95
chromosome 1 open reading frame 174 C1orf174 339448 7911897 40
chromosome 1 open reading frame 183 C1orf183 55924 7918552 85
chromosome 20 open reading frame 111 C20orf111 51526 8066402 65
chromosome 20 open reading frame 24 C20orf24 55969 8062326 20
chromosome 3 open reading frame 62//ubiquitin specific peptidase 4 (proto-oncogene) C3orf62//USP4 375341//7375 8087374 40
chromosome 9 open reading frame 89 C9orf89 84270 8156404 100
coactivator-associated arginine methyltransferase 1 CARM1 10498 8025766 60
CD33 molecule CD33 945 8030804 45
CD86 molecule CD86 942 8082035 45
CD93 molecule CD93 22918 8065359 50
cytochrome c oxidase subunit VIIa polypeptide 2 like COX7A2L 9167 8051777 45
corticotropin releasing hormone binding protein CRHBP 1393 8106418 45
chondroitin sulfate N-acetylgalactosaminyltransferase 2 CSGALNACT2 55454 7927146 90
cytochrome P450, fam. 51, subfam. A, polypeptide 1 CYP51A1 1595 8140864 85
DDRGK domain containing 1 DDRGK1 65992 8064601 60
DEAD (Asp-Glu-Ala-As) box polypeptide 19A DDX19A 55308 7997059 95
DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 DDX21 9188 7927936 60
24-dehydrocholesterol reductase DHCR24 1718 7916432 100
7-dehydrocholesterol reductase DHCR7 1717 7950067 80
DEAH (Asp-Glu-Ala-His) box polypeptide 33 DHX33 56919 8011861 100
DnaJ (Hsp40) homolog, subfam. B, member 4 DNAJB4 11080 7902512 100
DnaJ (Hsp40) homolog, subfam. B, member 9 DNAJB9 4189 8135480 25
DnaJ (Hsp40) homolog, subfam. C, member 5 DNAJC5 80331 8064208 10
DnaJ (Hsp40) homolog, subfam. C, member 9 DNAJC9 23234 7934320 55
DNA-damage regulated autophagy modulator 2//choline/ethanolamine phosphotransferase 1 DRAM2//CEPT1 128338//10390 7918474 100
D-tyrosyl-tRNA deacylase 1 homolog (S. cerevisiae) DTD1 92675 8061211 45
ER degradation enhancer, mannosidase alpha-like 2 EDEM2 55741 8065855 80
ecotropic viral integration site 2B EVI2B 2124 8014063 60
fam. with sequence similarity 36, member A//non-protein coding RNA 201 FAM36A//NCRNA00201 116228//284702 7911085 15
fam. with sequence similarity 86, member A FAM86A 196483 7999304 25
Fas (TNF receptor superfam., member 6) FAS 355 7929032 70
fatty acid synthase FASN 2194 8019392 100
F-box protein 10//translocase of outer mitochondrial membrane 5 homolog (yeast) FBXO10//TOMM5 26267//401505 8161229 40
MGC44478 FDPSL2A 619190 8140443 55
ferredoxin reductase FDXR 2232 8018236 40
forkhead box O4 FOXO4 4303 8168205 80
ferritin, heavy polypeptide-like 5 FTHL5 2509 8126948 95
fucosidase, alpha-L- 2, plasma FUCA2 2519 8129974 20
growth arrest-specific 2 like 3 GAS2L3 283431 7957850 70
ganglioside induced differentiation associated protein 2 GDAP2 54834 7918955 80
growth differentiation factor 11 GDF11 10220 7956026 65
glutaredoxin (thioltransferase) GLRX 2745 8113214 90
guanine nucleotide binding protein-like 3 (nucleolar)-like GNL3L 54552 8167797 85
glucosamine-phosphate N-acetyltransferase 1 GNPNAT1 64841 7979196 90
glutathione reductase GSR 2936 8150112 40
GTF2I repeat domain containing 2//GTF2I repeat domain containing 2B GTF2IRD2//GTF2IRD2B 84163//389524 8133549 and 8140170 50 and 30
general transcription factor IIIC, polypeptide 2, beta 110 kDa GTF3C2 2976 8051075 55
HMG-box transcription factor 1//component of oligomeric golgi complex 5 HBP1//COG5 26959//10466 8135392 65
histone cluster 1, H1c HIST1H1C 3006 8124397 45
histone cluster 1, H1e HIST1H1E 3008 8117377 95
histone cluster 1, H2ae HIST1H2AE 3012 8117408 45
histone cluster 1, H2be HIST1H2BE 8344 8117389 15
histone cluster 1, H3g HIST1H3G 8355 8124440 35
histone cluster 1, H3j HIST1H3J 8356 8124537 60
histone cluster 1, H4a HIST1H4A 8359 8117334 10
histone cluster 2, H2ac//histone cluster 2, H2aa3//histone cluster 2, H2aa4 HIST-2H2AC//2H2AA3//2H2AA4 8338//8337//723790 7905079 and 7919619 75 and 75
histone cluster 2, H2bf//histone cluster 2, H2be//histone cluster 2, H2ba HIST-2H2BF//2H2BE//2H2BA 440689//8349//337875 7919606 50
high-mobility group box 3 HMGB3 3149 8170468 5
3-hydroxy-3-methylglutaryl-Coenzyme A reductase//3-hydroxy-3-methylglutaryl-CoA reductase HMGCR//HMGCR 3156//3156 8106280 90
3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)//3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) HMGCS1//HMGCS1 3157//3157 8111941 80
heme oxygenase (decycling) 1 HMOX1 3162 8072678 10
heterogeneous nuclear ribonucleoprotein L HNRNPL 3191 8036613 30
insulin receptor substrate 2 IRS2 8660 7972745 35
iron-sulfur cluster scaffold homolog (E. coli) ISCU 23479 7958414 100
interferon stimulated exonuclease gene 20 kDa-like 2 ISG20L2 81875 7921110 45
potassium voltage-gated channel, Isk-related fam., member 3 KCNE3 10008 7950409 25
keratinocyte growth factor-like protein 1//fibroblast growth factor 7 (keratinocyte growth factor)//keratinocyte growth factor-like protein 2//hypothetical protein FLJ20444 KGFLP1//FGF7//KGFLP2//FLJ20444 387628//2252//654466//403323 8155530 70
lysophosphatidic acid receptor 1 LPAR1 1902 8163257 10
leucine-rich PPR-motif containing LRPPRC 10128 8051882 65
lymphocyte antigen 96 LY96 23643 8146934 35
mitogen-activated protein kinase kinase 1//small nuclear RNA activating complex, polypeptide 5, 19 kDa MAP2K1//SNAPC5 5604//10302 7984319 30
mitogen-activated protein kinase 13 MAPK13 5603 8119016 60
methyltransferase like 2A METTL2A 339175 8009008 45
microsomal glutathione S-transferase 3 MGST3 4259 7906978 70
mitochondrial ribosomal protein L30 MRPL30 51263 8043848 30
mitochondrial ribosomal protein L4 MRPL4 51073 8025586 40
mitochondrial ribosomal protein S17//glioblastoma amplified sequence//zinc finger protein 713 MRPS17//GBAS//ZNF713 51373//2631//349075 8132922 60
mitochondrial poly(A) polymerase//golgi autoantigen, golgin subfam. a, 6 pseudogene MTPAP//LOC729668 55149//729668 7932834 45
5-methyltetrahydrofolate-homocysteine methyltransferase MTR 4548 7910752 15
neighbor of BRCA1 gene 1 NBR1 4077 8007471 20
nuclear import 7 homolog (S. cerevisiae) NIP7 51388 7996934 75
NLR fam., pyrin domain containing 12 NLRP12 91662 8039096 35
nucleolar protein fam. 6 (RNA-associated) NOL6 65083 8160682 95
NAD(P)H dehydrogenase, quinone 1 NQO1 1728 8002303 45
nuclear receptor binding protein 1 NRBP1 29959 8040927 20
nucleotide binding protein-like NUBPL 80224 7973826 10
nudix (nucleoside diphosphate linked moiety X)-type motif 14 NUDT14 256281 7981566 35
nuclear fragile × mental retardation protein interacting protein 1 NUFIP1 26747 7971361 60
nucleoporin 153 kDa NUP153 9972 8124059 25
olfactory receptor, fam. 5, subfam. B, member 21 OR5B21 219968 7948330 50
PAS domain containing serine/threonine kinase PASK 23178 8060205 55
PRKC, apoptosis, WT1, regulator PAWR 5074 7965112 30
PDGFA associated protein 1 PDAP1 11333 8141273 35
phosphodiesterase 1B, calmodulin-dependent PDE1B 5153 7955943 85
phosphoribosylformylglycinamidine synthase PFAS 5198 8004804 60
pleckstrin homology-like domain, fam. A, member 3 PHLDA3 23612 7923372 75
phosphoinositide-3-kinase adaptor protein 1 PIK3AP1 118788 7935337 20
PTEN induced putative kinase 1 PINK1 65018 7898663 70
phosphomannomutase 2 PMM2 5373 7993148 65
partner of NOB1 homolog (S. cerevisiae) PNO1 56902 8042381 40
polymerase (RNA) II (DNA directed) polypeptide E, 25 kDa POLR2E 5434 8032149 80
polymerase (RNA) III (DNA directed) polypeptide E (80 kD) POLR3E 55718 7993973 30
protein phosphatase 1D magnesium-dependent, delta isoform//protein phosphatase, Mg2+/Mn2+ dependent, 1D PPM1D//PPM1D 8493//8493 8008922 80
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 PREX1 57580 8066848 100
proline-serine-threonine phosphatase interacting protein 1 PSTPIP1 9051 7985099 95
prothymosin, alpha PTMA 5757 7954006 and 7961022 20 and 15
RAB33B, member RAS oncogene fam. RAB33B 83452 8097507 40
renin binding protein RENBP 5973 8175933 65
replication factor C (activator 1) 2, 40 kDa RFC2 5982 8140151 30
ribonuclease H1 RNASEH1 246243 8050079 90
ring finger protein 146 RNF146 81847 8121927 50
ring finger protein 24 RNF24 11237 8064766 100
ring finger protein 26 RNF26 79102 7944510 95
ribosomal protein SA//small nucleolar RNA, H/ACA box 62 RPSA//SNORA62 3921//6044 8078918 75
RNA pseudouridylate synthase domain containing 2 RPUSD2 27079 7982753 45
ribosomal RNA processing 12 homolog (S. cerevisiae) RRP12 23223 7935425 75
retinoid × receptor, alpha RXRA 6256 8159127 5
scavenger receptor class B, member 2 SCARB2 950 8101158 70
SERPINE1 mRNA binding protein 1 SERBP1 26135 7916836 95
splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)//splicing factor proline/glutamine-rich SFPQ//SFPQ 6421//6421 7914791 40
solute carrier fam. 25, member 32//DDB1 and CUL4 associated factor 13 SLC25A32//DCAF13 81034//25879 8152255 100
solute carrier fam. 35, member B3 SLC35B3 51000 8123825 40
solute carrier fam. 37 (glucose-6-phosphate transporter), member 4 SLC37A4 2542 7952132 55
solute carrier fam. 5 (sodium-dependent vitamin transporter), member 6 SLC5A6 8884 8051030 95
sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) SMPD4 55627 8055183 40
small nucleolar RNA host gene 1 (non-protein coding)//small nucleolar RNA, C/D box 26 SNHG1//SNORD26 23642//9302 7948908 20
small nucleolar RNA host gene 12 (non-protein coding) SNHG12 85028 7914202 10
small nucleolar RNA, H/ACA box 45 SNORA45 677826 7938293 25
sorting nexin fam. member 27 SNX27 81609 7905444 35
spinster homolog 2 (Drosophila)//MYB binding protein (P160) 1a SPNS2//MYBBP1A 124976//10514 8011640 45
sprouty homolog 2 (Drosophila) SPRY2 10253 7972217 75
squalene epoxidase SQLE 6713 8148280 95
sterol regulatory element binding transcription factor 2 SREBF2 6721 8073522 45
ST3 beta-galactoside alpha-2,3-sialyltransferase 6 ST3GAL6 10402 8081219 100
serine/threonine kinase 17b STK17B 9262 8057887 90
transmembrane anterior posterior transformation 1 TAPT1 202018 8099506 65
taste receptor, type 2, member 5 TAS2R5 54429 8136647 40
tubulin folding cofactor E-like TBCEL 219899 7944623 55
tectonic fam. member 2 TCTN2 79867 7959638 40
toll-like receptor 6 TLR6 10333 8099841 30
transmembrane protein 150B TMEM150B 284417 8039453 25
transmembrane protein 55A TMEM55A 55529 8151756 90
transmembrane protein 59 TMEM59 9528 7916372 90
transmembrane protein 97 TMEM97 27346 8005839 95
tumor necrosis factor receptor superfam., member 10c, decoy without an intracellular domain TNFRSF10C 8794 8145244 75
translocase of outer mitochondrial membrane 34 TOMM34 10953 8066461 35
translocase of outer mitochondrial membrane 40 homolog (yeast) TOMM40 10452 8029521 40
tumor protein p53 inducible protein 3 TP53I3 9540 8050702 30
tumor protein p53 inducible nuclear protein 1 TP53INP1 94241 8151890 100
twinfilin, actin-binding protein, homolog 2 (Drosophila)//toll-like receptor 9 TWF2//TLR9 11344//54106 8087860 65
thioredoxin reductase 1 TXNRD1 7296 7958174 55
ubiquitin-fold modifier conjugating enzyme 1 UFC1 51506 7906662 95
ubiquitin specific peptidase 10 USP10 9100 7997633 30
vesicle-associated membrane protein 3 (cellubrevin) VAMP3 9341 7897370 40
valyl-tRNA synthetase VARS 7407 8125091 and 8178609 10 and 10
vacuolar protein sorting 37 homolog A (S. cerevisiae) VPS37A 137492 8144774 60
zinc finger protein 211 ZNF211 10520 8031792 45
zinc finger protein 223 ZNF223 7766 8029360 65
zinc finger protein 561 ZNF561 93134 8033795 60
zinc finger protein 79 ZNF79 7633 8158022 100
--- --- --- 7910385 40
--- --- --- 7946567 15
--- --- --- 7966223 45
--- --- --- 7979694 40
--- --- --- 8130495 30
--- --- --- 8180237 60
--- --- --- 8180268 85
--- --- --- 8180417 85
  1. The table shows the biomarker genes found by t-test and Backward Elimination. Genes were annotated, using the NetAffx database from Affymetrix (http://www.affymetrix.com, Santa Clara USA). When found, the Entrez Gene ID http://www.ncbi.nlm.nih.gov/gene was chosen as the gene identifier. The validation call frequency (%) is the occurrence of each gene in the 20 Test Gene Signatures obtained in the validation step.