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Table 4 Transcripts detected in O.novo-ulmi that occur in gene families described for other ascomycetous pathogens and may function in determining virulence and fitness.

From: Functional categorization of unique expressed sequence tags obtained from the yeast-like growth phase of the elm pathogen Ophiostoma novo-ulmi

Assigned protein identity

No. of copies

FunCat number

Putative function

Species occurrence of gene locus (citation)

Trichothecene C-15 hydroxylase

1

01.06

Mycotoxin pathway

FG, FS

[51, 52]

Isochorismatase family hydrolase

2

99

Response to plant defence mechanisms

MG, BC, SS, SN, AF

[FGI, 53]

Woronin body major protein

3

42.19

Cellular integrity

(seal septal pores in response to stress, important during host infection)

MG, filamentous ascomycetes

[FGI, 54]

Tetraspanin

2

99

Transmembrane protein implicated in penetration of host tissue

BC, MG, CL

[FGI, 55]

Cox17p, involved in copper metabolism and assembly of cytochrome oxidase

1

02.13; 70.10; 34.01

Cellular respiration (cytochrome C oxidase copper chaperone)

BC, MG, SS, SN, AN

(FGI)

Beta-glucanase/

beta-glucan synthetase

1

01.05, 42.01

Cell wall biogenesis

BC, SS, SN, AN, FS

[FGI, 56]

Copper-zinc superoxide dismutase

5

11.01; 11.07

Antioxidant defenses (conversion of superoxide radicals)

CN, PM

[57]

Glutathione peroxidase paralogue

1

11.07

Antioxidant defenses (reduction of lipid hydroperoxides)

BC, MG, SS, SN, CG

[FGI, 58]

Chitin synthase

(including type A, C, 3, class IV and class V)

12

01.05, 34.11, 42.03, 73.01

Cell wall biogenesis

AN, AF, CGr, MG, PB

[27]

Histidine kinase

1

14.07, 30.05

Global gene regulation

BD, HC

[41]

Glucan synthase

1

01.05

Cell wall biogenesis

BD, HC, PB

[58]

  1. Species acronyms: AN = Aspergillus nidulans, AF = Aspergillus flavus, BC = Botrytis cinerea, BD = Blastomyces dermatitidis, CGl = Chaetomium globosum, CGr = Colletotrichum graminicola, CL = Colletotrichum lindemuthianum, CN = Cryptococcus neoformans, FG = Fusarium graminearum (anamorph of Gibberella zeae), FS = Fusarium spp., HC = Histoplasma capsulatum, MG = Magnaporthe grisea, PB = Paracoccidioides braziliensis, PM = Penicillium marneffei, SN = Stagonospora nodorum, SS = Sclerotinia sclerotiorum. FGI = Fungal Genome Initiative, Broad Institute http://www.broad.mit.edu/annotation/fungi/fgi/index.html