Skip to main content

Table 3 P.aeruginosa genes affected in the ΔpppA-ppkA mutant compared to the PAO1 wild-type strain

From: A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence

Gene (Name)

Fold changea

P-value

Protein (Function)c

Other regulators

oxidative stress

primary metabolism

  

PA0106 (coxA)b

2.58

0.177

cytochrome c oxidase, subunit I (Energy metabolism)

RpoS, QS

PA0107b

3.68

0.091

CHP (Energy metabolism)

RpoS, QS

PA0108 (coIII)

2.22

0.038

cytochrome c oxidase, transmembrabe helix, subunit III (Energy metabolism)

RpoS, QS

PA1317 (cyoA)

-3.08

0.013

cytochrome o ubiquinol oxidase subunit II (Energy metabolism)

QS

PA1318 (cyoB)

-2.79

0.009

cytochrome o ubiquinol oxidase subunit I (Energy metabolism)

QS

PA1319 (cyoC)

-2.39

0.043

cytochrome o ubiquinol oxidase subunit III (Energy metabolism)

QS

PA1320 (cyoD)

-2.27

0.041

cytochrome o ubiquinol oxidase subunit IV (Energy metabolism)

QS

PA1321 (cyoE)

-3.86

0.037

cytochrome o ubiquinol oxidase protein CyoE (Energy metabolism)

QS

sulphur metabolism

  

PA0283 (sbp)b

4.89

0.061

sulfate-binding protein precursor, ABC transporter (Transport of small molecules)

 

PA0284

10.61

0.038

HP

PQS

PA1493 (cysP)

4.73

0.004

sulfate-binding protein of ABC transporter (Transport of small molecules)

 

PA1754 (cysB)

1.73

0.022

transcriptional regulator CysB (Amino acid biosynthesis and metabolism)

 

PA1838 (cysI)b

2.80

0.051

sulfite reductase (Central intermediary metabolism)

 

PA3441

2.76

0.027

Pr. molybdopterin-binding protein (Transport of small molecules)

 

PA3450

8.46

0.047

Pr. antioxidant protein (Adaptation, protection) Probable Alkyl hydroperoxide reductase

 

PA3935 (tauD)

1.81

0.037

taurine dioxygenase (Carbon compound catabolism)

RpoS

PA3936 (tauC)b

2.92

0.080

Pr. permease of ABC taurine transporter (Membrane proteins; Transport of small molecules)

RpoS

PA3938 (tauA)

5.07

0.025

Pr. periplasmic taurine-binding protein precursor (Transport of small molecules)

RpoS

PA4442 (cysN)b

3.13

0.117

ATP sulfurylase GTP-binding subunit/APS kinase (Amino acid biosynthesis and metabolism; Central intermediary metabolism)

QS

PA4443 (cysD)b

4.86

0.051

ATP sulfurylase small subunit (Amino acid biosynthesis and metabolism; Central intermediary metabolism)

QS

others

    

PA0594 (surA)

2.03

0.036

peptidyl-prolyl cis-trans isomerase SurA (Adaptation, protection)

 

PA1127b

-2.94

0.061

Pr. oxidoreductase (Adaptation, protection; Putative enzymes)

 

RpoS regulated genes

  

PA1708 (popB)b

-2.08

0.070

translocator protein PopB (Protein secretion/export apparatus)

QS, TTSS

PA1709 (popD)

-1.82

0.004

translocator protein PopD (Protein secretion/export apparatus)

QS, TTSS

PA4551 (pilV)

-2.09

0.008

type 4 fimbrial biogenesis protein PilV (Motility & Attachment)

 

PA1048

2.80

0.037

Pr. outer membrane protein (Membrane proteins; Transport of small molecules)

 

PA1119

1.95

0.021

Pr. outer membrane lipoprotein (Membrane proteins)

 

PA1175 (napD)

1.88

0.021

NapD protein of periplasmic nitrate reductase (Energy metabolism)

QS

PA2204

1.87

0.014

Pr. binding protein component of ABC transporter (Transport of small molecules)

PQS

PA2223

2.76

0.021

HP

 

PA2235

2.11

0.017

HP

 

PA2303

1.80

0.035

HP

QS

PA2365

1.96

0.017

CHP

QS

PA2366

2.05

0.001

CHP

QS

PA2452

1.76

0.033

HP

 

PA2570 (pa1L)

2.47

0.049

PA-I galactophilic lectin (Adaptation, protection; Motility & Attachment)

QS

PA2781

2.06

0.027

HP

 

PA2939

4.49

0.018

Pr. aminopeptidase (Putative enzymes)

QS

PA3622 (rpoS)

3.86

0.030

sigma factor RpoS (Transcriptional regulators)

PQS

PA3848

1.93

0.020

HP

 

PA4175 (prpL)

4.65

0.008

protease IV (Secreted Factors (toxins, enzymes, alginate))

QS

PA4296 (pprB)

3.69

0.029

PprB two-component response regulator (Transcriptional regulators; Two-component regulatory systems; Antibiotic resistance and susceptibility)

QS

PA4299 (tadD)b

2.41

0.086

tadD Flp pilus assembly protein (Function Motility & Attachment)

PprB, QS

PA4306 (flp)

6.69

0.002

Flp Type IVb pilin (Motility & Attachment)

PprB, QS

QS regulated genes

PA0572

3.27

0.049

HP

 

PA1874

2.02

0.048

HP

 

PA2067

2.38

0.039

Pr. hydrolase (Putative enzymes)

 

PA3724 (lasB)

2.23

0.037

elastase LasB (Translation, post-translational modification, degradation; Secreted Factors (toxins, enzymes, alginate))

RpoS, PQS

PA3922

11.31

0.038

CHP

 

PA3923b

8.11

0.143

HP

 

PA4497

2.61

0.031

Pr. binding protein component of ABC transporter (Transport of small molecules)

 

PA5481

2.01

0.038

HP

 

PQS/MvfR regulon

PA0200

5.10

0.048

HP

 

PA0201

5.10

0.048

HP

 

PA0996 (pqsA)

4.56

0.011

Pr. coenzyme A ligase (Biosynthesis of cofactors, prosthetic groups and carriers)

 

PA0997 (pqsB)

2.05

0.007

Homologous to beta-keto-acyl-acyl-carrier protein synthase (Biosynthesis of cofactors, prosthetic groups and carriers)

 

PA0998 (pqsC)

2.07

0.038

Homologous to beta-keto-acyl-acyl-carrier protein synthase (Biosynthesis of cofactors, prosthetic groups and carriers)

 

PA0999 (pqsD)

2.24

0.009

3-oxoacyl-[acyl-carrier-protein] synthase III (Biosynthesis of cofactors, prosthetic groups and carriers)

 

PA1000 (pqsE)

2.50

0.016

Quinolone signal response protein (Biosynthesis of cofactors, prosthetic groups and carriers)

 

PA1001 (phnA)b

2.54

0.065

anthranilate synthase component I (Adaptation, protection)

 

PA1002 (phnB)b

2.19

0.071

anthranilate synthase component II (Adaptation, protection; Amino acid biosynthesis and metabolism

 

PA3520

2.31

0.020

HP

oxidative stress

PA4377

3.01

0.022

HP

 

other genes

    

PA4139

12.71

0.018

HP

 
  1. a Fold changes represent the ratio of the expression levels in the comparison of P. aeruginosa ΔpppA-ppkA and wild type PAO1. Minus (-) sign indicates a decreased expression in ΔpppA-ppkA mutant strain;b p-value > 0.05, only genes from the same transcriptional unit are listed;c HP - hypothetical protein, CHP- conserved hypothetical protein, Pr. - probable
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us