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Table 1 Adipogenic candidate genes and their involvement in biochemical pathways.

From: Differential gene expression profiling of human bone marrow-derived mesenchymal stem cells during adipogenic development

Pathway

Candidate genes

PPARG signalling pathway

Up-regulated: RXRA, C/EBPA, CES1, PPARG, GPD1

Adipocyte differentiation pathway

Up-regulated: FABP4, PLIN

Adipocytokine signalling pathway

Up-regulated: LPL, ADIPOQ, APOE, LGALS3, COL5A3,

APOL6, CLEC1A, FLRT3

Lipogenesis pathway

Up-regulated: HADHSC, SCD, FASN, DGAT2,

SRD5A2L, ACACB

Insulin-like signalling pathway

Up-regulated: IGFBP5, INSIG1, IGF1R, GHR, IGF1

Down-regulated:,IGFBP7

Apoptosis(factors related to, or no pathway)

Up-regulated: ACVR1C, AOC3, C1QTNF1, C7, CFLAR, CIDEC, DDX17, LASP8, PI-3-kinase, RBM5, SMG1

Down-regulated: BID, HNRPC, MORF4L2, PAWR, SULF1

  1. The 184 selected genes were analyzed in different online databases (DAVID, KEGG and iHOP), for example in gene studies and the gene products were subsequently in biochemical pathway studies performed. Genes, up-regulated during adipogenesis were of most interest. This Table 1 shows pathways and corresponding genes. For gene names and mean signal values see the Additional files 1 and 2. Charts that illustrate expression values as a function of time are presented in Figure 7 and Figure 8.
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BMC Genomics

ISSN: 1471-2164

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