Distribution of HBS and enrichment of transcription factor binding sites in the upstream of genes altered in HD. A. HBS distribution along the 10 Kb upstream regions of the genes altered in microarray study carried out with HD patients. Distance was calculated taking the transcription start site (TSS) as '0'. Frequency of occurrence of HBS per kb distance was plotted against the distance from TSS as described in legend of Figure 1. B. Enrichment of transcription factor binding sites in the 10 Kb upstream of genes up-regulated in HD microarray. As described in Figure 3A, the occurrence of a particular binding motif in the set of up-regulated genes was compared to the background occurrence of that motif and plotted against the TF. The p value in the figure represents the significance level of enrichment for the transcription factor. C. Enrichment of transcription factor binding sites in the 10 Kb upstream of genes down-regulated in HD microarray as described above.