Table 1 GO Molecular Function and Biological Process analysis of the genes having HBS within 2 Kb upstream sequence
From: Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: Prediction and validation
Molecular functions | ||||||
|---|---|---|---|---|---|---|
GO ID | GO details | Data set frequency (%) | Background frequency (%) | p value (unadjusted) | p value (corrected) | Gene name |
GO:0004872 | Receptor activity | 9.84549 | 5.767347 | 5.71E-20 | 1.10E-17 | Transforming growth factor, beta receptor 1, glutamate receptor, ionotropic, N-methyl D-aspartate 2D, gamma-aminobutyric acid (GABA) B receptor, 2 |
GO:0043565 | Sequence-specific DNA binding | 4.132231 | 2.602547 | 2.88E-07 | 9.29E-06 | cAMP responsive element binding protein 1, Activating transcription factor 2, CCAAT/enhancer binding protein (C/EBP), gamma, POU class 4 homeobox 2 |
GO:0003700 | Transcription factor activity | 6.324111 | 4.527836 | 2.17E-06 | 6.00E-05 | CREB/ATF bZIP transcription factor, cAMP responsive element binding protein 1, activating transcription factor 2, Signal transducer and activator of transcription 4, Transcription factor AP-2 beta |
GO:0030528 | Transcription regulator activity | 3.162055 | 1.967883 | 4.25E-06 | 0.00010965 | Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein, POU class 4 homeobox 2, HMG-box transcription factor 1 |
GO:0003682 | Chromatin binding | 1.401365 | 0.758189 | 0.0001005 | 0.001620659 | CREB binding protein, RE1-silencing transcription factor, polymerase (DNA directed), alpha 1, catalytic subunit, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 |
Biological process | ||||||
GO:0007165 | Signal transduction | 14.94077 | 8.710653 | 6.47E-29 | 3.07E-26 | Protein kinase, cAMP-dependent, regulatory, type II, beta, CREB binding protein, cAMP responsive element modulator, Transforming growth factor, beta receptor 1, cAMP responsive element binding protein 1, Caspase 1, apoptosis-related cysteine peptidase |
GO:0006355 | Regulation of transcription, DNA-dependent | 9.70577 | 5.865315 | 1.04E-16 | 9.88E-15 | CREB binding protein, Nuclear transcription factor Y, alpha, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4, cAMP responsive element binding protein 1, Cyclin-dependent kinase inhibitor 2A |
GO:0006412 | Translation | 3.018724 | 1.682498 | 1.67E-07 | 7.21E-06 | Eukaryotic translation initiation factor 6, WD repeat-containing protein 46 |
GO:0007268 | Synaptic transmission | 1.337409 | 0.694297 | 0.000101 | 0.001916701 | Synapsin I, Neurexin 2, Amyloid beta (A4) precursor protein-binding, family A, member 1, Glutamate decarboxylase 1 (brain, 67 kDa), Gamma-aminobutyric acid (GABA) B receptor, 2 |
GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | 2.216278 | 1.478042 | 0.001084 | 0.01355529 | Nuclear transcription factor Y, alpha, Transforming growth factor, beta 3, CREB binding protein, SMAD family member 4, Thyroid hormone receptor, beta, |
GO:0008630 | DNA damage response, signal transduction resulting in induction of apoptosis | 0.22927 | 0.068152 | 0.005672 | 0.04954832 | Methyl-CpG binding domain protein 4. Ataxia telangiectasia mutated. CHK2 checkpoint homolog (S. pombe) |