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Table 1 GO Molecular Function and Biological Process analysis of the genes having HBS within 2 Kb upstream sequence

From: Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: Prediction and validation

Molecular functions
GO ID GO details Data set frequency (%) Background frequency (%) p value (unadjusted) p value (corrected) Gene name
GO:0004872 Receptor activity 9.84549 5.767347 5.71E-20 1.10E-17 Transforming growth factor, beta receptor 1, glutamate receptor, ionotropic, N-methyl D-aspartate 2D, gamma-aminobutyric acid (GABA) B receptor, 2
GO:0043565 Sequence-specific DNA binding 4.132231 2.602547 2.88E-07 9.29E-06 cAMP responsive element binding protein 1, Activating transcription factor 2, CCAAT/enhancer binding protein (C/EBP), gamma, POU class 4 homeobox 2
GO:0003700 Transcription factor activity 6.324111 4.527836 2.17E-06 6.00E-05 CREB/ATF bZIP transcription factor, cAMP responsive element binding protein 1, activating transcription factor 2, Signal transducer and activator of transcription 4, Transcription factor AP-2 beta
GO:0030528 Transcription regulator activity 3.162055 1.967883 4.25E-06 0.00010965 Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein, POU class 4 homeobox 2, HMG-box transcription factor 1
GO:0003682 Chromatin binding 1.401365 0.758189 0.0001005 0.001620659 CREB binding protein, RE1-silencing transcription factor, polymerase (DNA directed), alpha 1, catalytic subunit, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Biological process
GO:0007165 Signal transduction 14.94077 8.710653 6.47E-29 3.07E-26 Protein kinase, cAMP-dependent, regulatory, type II, beta, CREB binding protein, cAMP responsive element modulator, Transforming growth factor, beta receptor 1, cAMP responsive element binding protein 1, Caspase 1, apoptosis-related cysteine peptidase
GO:0006355 Regulation of transcription, DNA-dependent 9.70577 5.865315 1.04E-16 9.88E-15 CREB binding protein, Nuclear transcription factor Y, alpha, Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4, cAMP responsive element binding protein 1, Cyclin-dependent kinase inhibitor 2A
GO:0006412 Translation 3.018724 1.682498 1.67E-07 7.21E-06 Eukaryotic translation initiation factor 6, WD repeat-containing protein 46
GO:0007268 Synaptic transmission 1.337409 0.694297 0.000101 0.001916701 Synapsin I, Neurexin 2, Amyloid beta (A4) precursor protein-binding, family A, member 1, Glutamate decarboxylase 1 (brain, 67 kDa), Gamma-aminobutyric acid (GABA) B receptor, 2
GO:0045944 Positive regulation of transcription from RNA polymerase II promoter 2.216278 1.478042 0.001084 0.01355529 Nuclear transcription factor Y, alpha, Transforming growth factor, beta 3, CREB binding protein, SMAD family member 4, Thyroid hormone receptor, beta,
GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis 0.22927 0.068152 0.005672 0.04954832 Methyl-CpG binding domain protein 4. Ataxia telangiectasia mutated. CHK2 checkpoint homolog (S. pombe)