From: Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: Prediction and validation
Up-regulated | ||||||
---|---|---|---|---|---|---|
Molecular function | ||||||
GO ID | GO details | Data set frequency (%) | Background frequency (%) | p value (unadjusted) | p value (corrected) | Gene name |
GO:0003700 | Transcription factor activity | 9.881422925 | 4.527835754 | 2.14E-07 | 3.54E-05 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, NK2 transcription factor related, locus 5 (Drosophila), CCAAT/enhancer binding protein (C/EBP), beta, CREB binding protein |
GO:0003702 | RNA polymerase II transcription factor activity | 2.56916996 | 0.575030881 | 7.44E-06 | 0.000531586 | Forkhead box E1 (thyroid transcription factor 2), Transcription elongation regulator 1 |
GO:0016564 | Transcription repressor activity | 2.766798419 | 0.72837245 | 8.03E-06 | 0.0011916 | Peroxisome proliferator-activated receptor delta, RE1-silencing transcription factor, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39 kDa |
GO:0003682 | Chromatin binding | 2.56916996 | 0.758188866 | 2.16E-05 | 0.004496337 | NK2 transcription factor related, locus 5 (Drosophila), CREB binding protein, RE1-silencing transcription factor |
GO:0003713 | Transcription co-activator activity | 2.56916996 | 0.796524258 | 3.49E-05 | 0.006663331 | Transcription elongation regulator 1, junction mediating and regulatory protein, p53 cofactor, CREB binding protein |
GO:0043565 | Sequence-specific DNA binding | 5.335968379 | 2.602547174 | 3.57E-05 | 0.01057545 | v-rel reticuloendotheliosis viral oncogene homolog A (avian), CCAAT/enhancer binding protein (C/EBP), beta, NK2 transcription factor related, locus 5 (Drosophila) |
Biological process | ||||||
GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | 3.29218107 | 1.086169442 | 9.09E-05 | 0.01248966 | SIN3 homolog B, transcription regulator (yeast), RE1-silencing transcription factor |
GO:0006355 | Regulation of transcription, DNA-dependent | 10.08230453 | 5.865314989 | 0.000119 | 0.01575762 | Y box binding protein 1, POU class 2 homeobox 2, NK2 transcription factor related, locus 5 (Drosophila), CCAAT/enhancer binding protein (C/EBP), beta |
GO:0045893 | Positive regulation of transcription, DNA-dependent | 1.851851852 | 0.442986753 | 0.000161 | 0.02283294 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B |
GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | 3.703703704 | 1.478042339 | 0.000366 | 0.02283294 | Zinc finger and BTB domain containing 38, CCAAT/enhancer binding protein (C/EBP), beta, CREB binding protein, Tumor necrosis factor receptor superfamily, member 1A |
GO:0006412 | Translation | 3.909465021 | 1.682497764 | 0.000502 | 0.03143108 | Eukaryotic translation initiation factor 1B, Eukaryotic translation initiation factor 6 |
Down-regulated | ||||||
Molecular functions | ||||||
GO:0004888 | Transmembrane receptor activity | 3.140096618 | 0.694296546 | 6.83E-06 | 0.00066934 | G protein-coupled receptor 123, Toll-like receptor 6 |
GO:0016564 | Transcription repressor activity | 2.415458937 | 0.72837245 | 4.91E-05 | 0.02326809 | MYB binding protein (P160) 1a, Runt-related transcription factor 1; translocated to, 1 (cyclin D-related) |
GO:0003714 | Transcription co-repressor activity | 1.93236715 | 0.621885249 | 0.000116133 | 0.0479129 | Nuclear receptor interacting protein 1, Histone deacetylase 9 |
Biological process | ||||||
GO:0007165 | signal transduction | 18.29896907 | 8.71065298 | 1.50E-09 | 1.06E-06 | Ataxia telangiectasia mutated, Somatostatin receptor 2, Protein kinase, cAMP-dependent, regulatory, type II, alpha, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
GO:0007268 | synaptic transmission | 2.835051546 | 0.694296546 | 4.92E-07 | 0.005691273 | Neurexin 2, Potassium channel, subfamily K, member 3, Somatostatin |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 3.350515464 | 1.086169442 | 2.23E-06 | 0.01540901 | Nuclear receptor interacting protein 1, SP100 nuclear antigen, POU class 3 homeobox 3 |