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Table 3 Functional classification of the altered genes in microarray study by Gene Ontology

From: Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: Prediction and validation

Up-regulated
Molecular function
GO ID GO details Data set frequency (%) Background frequency (%) p value (unadjusted) p value (corrected) Gene name
GO:0003700 Transcription factor activity 9.881422925 4.527835754 2.14E-07 3.54E-05 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, NK2 transcription factor related, locus 5 (Drosophila), CCAAT/enhancer binding protein (C/EBP), beta, CREB binding protein
GO:0003702 RNA polymerase II transcription factor activity 2.56916996 0.575030881 7.44E-06 0.000531586 Forkhead box E1 (thyroid transcription factor 2), Transcription elongation regulator 1
GO:0016564 Transcription repressor activity 2.766798419 0.72837245 8.03E-06 0.0011916 Peroxisome proliferator-activated receptor delta, RE1-silencing transcription factor, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39 kDa
GO:0003682 Chromatin binding 2.56916996 0.758188866 2.16E-05 0.004496337 NK2 transcription factor related, locus 5 (Drosophila), CREB binding protein, RE1-silencing transcription factor
GO:0003713 Transcription co-activator activity 2.56916996 0.796524258 3.49E-05 0.006663331 Transcription elongation regulator 1, junction mediating and regulatory protein, p53 cofactor, CREB binding protein
GO:0043565 Sequence-specific DNA binding 5.335968379 2.602547174 3.57E-05 0.01057545 v-rel reticuloendotheliosis viral oncogene homolog A (avian), CCAAT/enhancer binding protein (C/EBP), beta, NK2 transcription factor related, locus 5 (Drosophila)
Biological process
GO:0000122 Negative regulation of transcription from RNA polymerase II promoter 3.29218107 1.086169442 9.09E-05 0.01248966 SIN3 homolog B, transcription regulator (yeast), RE1-silencing transcription factor
GO:0006355 Regulation of transcription, DNA-dependent 10.08230453 5.865314989 0.000119 0.01575762 Y box binding protein 1, POU class 2 homeobox 2, NK2 transcription factor related, locus 5 (Drosophila), CCAAT/enhancer binding protein (C/EBP), beta
GO:0045893 Positive regulation of transcription, DNA-dependent 1.851851852 0.442986753 0.000161 0.02283294 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
GO:0045944 Positive regulation of transcription from RNA polymerase II promoter 3.703703704 1.478042339 0.000366 0.02283294 Zinc finger and BTB domain containing 38, CCAAT/enhancer binding protein (C/EBP), beta, CREB binding protein, Tumor necrosis factor receptor superfamily, member 1A
GO:0006412 Translation 3.909465021 1.682497764 0.000502 0.03143108 Eukaryotic translation initiation factor 1B, Eukaryotic translation initiation factor 6
Down-regulated
Molecular functions
GO:0004888 Transmembrane receptor activity 3.140096618 0.694296546 6.83E-06 0.00066934 G protein-coupled receptor 123, Toll-like receptor 6
GO:0016564 Transcription repressor activity 2.415458937 0.72837245 4.91E-05 0.02326809 MYB binding protein (P160) 1a, Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
GO:0003714 Transcription co-repressor activity 1.93236715 0.621885249 0.000116133 0.0479129 Nuclear receptor interacting protein 1, Histone deacetylase 9
Biological process
GO:0007165 signal transduction 18.29896907 8.71065298 1.50E-09 1.06E-06 Ataxia telangiectasia mutated, Somatostatin receptor 2, Protein kinase, cAMP-dependent, regulatory, type II, alpha, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
GO:0007268 synaptic transmission 2.835051546 0.694296546 4.92E-07 0.005691273 Neurexin 2, Potassium channel, subfamily K, member 3, Somatostatin
GO:0000122 negative regulation of transcription from RNA polymerase II promoter 3.350515464 1.086169442 2.23E-06 0.01540901 Nuclear receptor interacting protein 1, SP100 nuclear antigen, POU class 3 homeobox 3