Table 3 Functional classification of the altered genes in microarray study by Gene Ontology

GO:0003700

Transcription factor activity

9.881422925

4.527835754

2.14E-07

3.54E-05

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, NK2 transcription factor related, locus 5 (Drosophila), CCAAT/enhancer binding protein (C/EBP), beta, CREB binding protein

GO:0003702

RNA polymerase II transcription factor activity

2.56916996

0.575030881

7.44E-06

0.000531586

Forkhead box E1 (thyroid transcription factor 2), Transcription elongation regulator 1

GO:0016564

Transcription repressor activity

2.766798419

0.72837245

8.03E-06

0.0011916

Peroxisome proliferator-activated receptor delta, RE1-silencing transcription factor, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39 kDa

GO:0003682

Chromatin binding

2.56916996

0.758188866

2.16E-05

0.004496337

NK2 transcription factor related, locus 5 (Drosophila), CREB binding protein, RE1-silencing transcription factor

GO:0003713

Transcription co-activator activity

2.56916996

0.796524258

3.49E-05

0.006663331

Transcription elongation regulator 1, junction mediating and regulatory protein, p53 cofactor, CREB binding protein

GO:0043565

Sequence-specific DNA binding

5.335968379

2.602547174

3.57E-05

0.01057545

v-rel reticuloendotheliosis viral oncogene homolog A (avian), CCAAT/enhancer binding protein (C/EBP), beta, NK2 transcription factor related, locus 5 (Drosophila)

Biological process

GO:0000122

Negative regulation of transcription from RNA polymerase II promoter

3.29218107

1.086169442

9.09E-05

0.01248966

SIN3 homolog B, transcription regulator (yeast), RE1-silencing transcription factor

GO:0006355

Regulation of transcription, DNA-dependent

10.08230453

5.865314989

0.000119

0.01575762

Y box binding protein 1, POU class 2 homeobox 2, NK2 transcription factor related, locus 5 (Drosophila), CCAAT/enhancer binding protein (C/EBP), beta

GO:0045893

Positive regulation of transcription, DNA-dependent

1.851851852

0.442986753

0.000161

0.02283294

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

GO:0045944

Positive regulation of transcription from RNA polymerase II promoter

3.703703704

1.478042339

0.000366

0.02283294

Zinc finger and BTB domain containing 38, CCAAT/enhancer binding protein (C/EBP), beta, CREB binding protein, Tumor necrosis factor receptor superfamily, member 1A

GO:0006412

Translation

3.909465021

1.682497764

0.000502

0.03143108

Eukaryotic translation initiation factor 1B, Eukaryotic translation initiation factor 6

Down-regulated

Molecular functions

GO:0004888

Transmembrane receptor activity

3.140096618

0.694296546

6.83E-06

0.00066934

G protein-coupled receptor 123, Toll-like receptor 6

GO:0016564

Transcription repressor activity

2.415458937

0.72837245

4.91E-05

0.02326809

MYB binding protein (P160) 1a, Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

GO:0003714

Transcription co-repressor activity

1.93236715

0.621885249

0.000116133

0.0479129

Nuclear receptor interacting protein 1, Histone deacetylase 9

Biological process

GO:0007165

signal transduction

18.29896907

8.71065298

1.50E-09

1.06E-06

Ataxia telangiectasia mutated, Somatostatin receptor 2, Protein kinase, cAMP-dependent, regulatory, type II, alpha, Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

GO:0007268

synaptic transmission

2.835051546

0.694296546

4.92E-07

0.005691273

Neurexin 2, Potassium channel, subfamily K, member 3, Somatostatin

GO:0000122

negative regulation of transcription from RNA polymerase II promoter

3.350515464

1.086169442

2.23E-06

0.01540901

Nuclear receptor interacting protein 1, SP100 nuclear antigen, POU class 3 homeobox 3