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Table 1 Cell cycle and cell growth genes responsive to MYC-ERTAM activation

From: Deciphering c-MYC-regulated genes in two distinct tissues

   Pancreatic β-Cells Suprabasal Keratinocytes  
Gene Symbol RefSeq 4 Hours 8 Hours 16 Hours 32 Hours 4 Hours 8 Hours 16 Hours 32 Hours Myc-response p-value
Cell Cycle           
ccna2 X75483 0.96 4.52** 10.49** 3.25** 0.81 0.67 1.39 0.97 2.05E-02
ccna2 X75483 0.55** 1.33* 12.39** 3.47** 0.63** 0.71* 0.99 1.05 1.12E-02
ccnb1 NM_007629 1.02 0.90 2.38** 1.13 0.48** 1.03 1.01 0.58** 9.74E-03
ccnb1 NM_007629 1.06 2.85** 8.15** 3.62** 0.60 0.46* 1.39 0.61 3.73E-02
ccnd1 NM_007631 1.86** 2.09** 0.88 1.45 1.13 1.31 1.79* 1.04 4.55E-02
ccnd1 NM_007631 1.69 2.38 1.41 2.27* 1.05 1.33 1.72 1.26 2.24E-02
ccnd1 NM_007631 3.41** 2.74* 2.03* 2.05 1.35 0.99 1.54 1.81 2.23E-02
ccnd2 NM_009829 1.63* 0.61* 2.28** 2.95** 1.37 1.46 0.94 1.40 2.62E-02
ccnd2 NM_009829 1.82 1.03 1.22 1.90* 0.83 1.33 0.97 1.78 1.48E-02
ccnd2 NM_009829 2.06** 2.04** 1.27 2.30** 0.90 0.84 1.29 0.84 1.21E-02
ccnd2 AK007904 1.99** 0.64* 1.88** 2.62** 1.66* 2.57** 1.00 2.13** 1.28E-03
ccnd2 NM_009829 2.09* 1.00 1.06 2.01* 1.26 0.96 1.12 1.51 2.38E-02
ccnd3 NM_007632 1.26* 0.84 1.54** 1.20 0.81* 2.58** 0.84 3.33** 8.71E-04
ccne1 NM_007633 1.82** 3.37** 7.02** 1.71* 0.94 1.35 1.15 1.82** 2.52E-02
ccne1 BB293079 1.83** 6.68** 1.87** 2.04** 0.85 1.50* 1.16 1.29 1.02E-02
ccne2 AF091432 2.62** 5.86** 5.92** 7.86** 1.74 1.11 1.42 1.39 1.45E-02
cdc2a NM_007659 0.95 2.91** 11.93** 3.35** 0.51* 1.17 0.89 1.12 4.33E-02
cdc25a C76119 2.71** 2.23** 2.09** 3.90** 1.11 0.46** 1.07 0.78 1.84E-03
cdc25a C76119 2.17** 1.73* 2.03** 2.10** 1.02 1.14 1.1 1.21 2.45E-02
cdk4 NM_009870 1.16 0.92 8.41** 1.11 1.32 12.27** 0.74 1.62 2.70E-02
cdk4 NM_009870 1.21 0.74 5.31** 1.5 1.23 11.30** 0.92 1.48 3.31E-02
cdk4 NM_009870 1.20 0.88 5.03** 1.3 1.37 11.17** 0.72 1.37 3.45E-02
cdk7 U11822 0.63* 0.77 3.69** 3.45** 0.82 2.12** 1.09 1.59* 1.37E-02
cks2 NM_025415 0.92 3.03** 10.08** 4.80** 0.51** 0.76 1.27 0.71 4.37E-03
cks2 NM_025415 0.98 2.33** 8.92** 2.34** 0.63* 0.92 0.93 1.32 1.18E-02
pcna BC010343 1 2.44** 17.91** 4.75** 1.32 3.24** 0.76 3.08** 3.38E-02
pcnt NM_008787 2.70** 3.79** 5.22** 4.18** 1.14 1.89** 1.10 1.82** 5.43E-06
Cell Cycle Arrest          
cdkn1a AK007630 1.57** 2.05** 1.71** 1.24 0.96 1.44* 0.99 0.90 5.01E-03
cdkn1b NM_009875 1.03 0.19** 0.71 0.95 0.23** 0.42* 0.48* 0.89 1.02E-02
cdkn2a NM_009877 2.17** 1.79** 1.57** 2.61** 1.21 1.07 1.07 0.87 8.43E-03
cdkn2c BC027026 0.32** 1.18 5.62** 0.59* 0.85 1.28 0.87 1.60* 9.38E-03
gadd45g AK007410 0.59* 0.41** 1.88** 0.59** 4.07** 5.16** 3.39** 2.78** 5.95E-03
gas6 NM_019521 0.60** 0.73** 1.02 0.90 1.39** 2.61** 1.43** 5.62** 2.31E-02
ing3 BB298005 0.90 1.12 1.15 0.66** 0.79 0.49** 0.77* 1.34* 1.50E-02
Cell Growth and Cytoskeleton Organization        
add1 BF140063 0.99 0.96 1.16 0.96 0.85 2.57** 0.86 3.93** 1.94E-02
add1 BF140063 0.82 0.80 0.62** 0.56** 1.25 2.41** 1.24 0.44** 8.01E-03
cap1 NM_007598 4.88* 0.80 1.16 1.14 1.50 8.59** 0.87 0.17** 4.61E-02
cfl1 NM_007687 1.29 0.51** 1.30 1.89** 1.03 2.28** 1.15 2.14** 4.26E-02
creg1 BC027426 1.06 0.83 2.39** 1.72** 0.82 1.54* 0.69* 1.09 3.57E-02
creg1 BC027426 2.08** 2.12** 1.60** 2.16** 0.69* 0.85 0.98 0.92 3.68E-02
egf NM_010113 1.05 0.79 0.92 1.38* 1.62** 0.47** 0.91 0.84 1.28E-02
lsp1 NM_019391 0.90 0.78* 0.97 1.10 1.02 3.42** 0.67** 1.90** 3.22E-02
myh4 BG794681 0.99 1.25 0.65 1.06 1.72 2.94* 0.94 1.55 8.16E-03
pdlim3 NM_016798 1.00 1.09 1.07 0.78 0.85 2.73** 1.49* 2.29** 4.52E-02
plec1 BM210485 1.31 0.49* 1.25 3.10** 0.53 1.38 1.04 2.87** 2.42E-02
plec1 BM232239 1.20 0.77 1.35 2.46** 3.23** 4.56** 2.82** 0.59* 2.09E-03
tuba3a NM_009446 0.97 0.97 1.13 1.00 0.83 3.09** 0.89 3.20** 1.22E-02
tubb2c BC005547 1.06 1.04 4.72** 1.48* 1.13 2.01** 1.04 1.41* 3.23E-02
tubb6 NM_026473 1.21 0.90 2.95** 1.71* 0.97 2.99** 1.28 3.49** 2.41E-02
  1. Selected MYC-responsive genes relating to cell growth and cell proliferation. 'MYC-response p-value' is the p-value identified for the highest-order interaction of the MYC activation variable and represents the significance of this term within the selected model. Flags represent contrast p-values comparing 4OHT-treated and vehicle-treated samples at specific time points ('*', p ≤ 0.05; '**' p ≤ 0.01). Cells are colour-coded based on a detected fold-change greater than 1.5-fold (red, up-regulated; blue, down-regulated)