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Table 3 IC50 values for Cp CDPK1 inhibitors tested.

From: The Cryptosporidium parvum Kinome

Compound IC50 (nM)
1.3 ± 0.2
2.1 ± 0.2
2.1 ± 0.3
2.8 ± 0.2
3.4 ± 0.1
3.4 ± 0.1
0.9 ± 0.1
2.6 ± 0.1
4.7 ± 0.4
7 ± 0.2
5.6 ± 0.5
15.2 ± 4.4
5.6 ± 0.8
7.7 ± 1
22 ± 2
249 ± 73
96 ± 13
88 ± 0.14
616 ± 203
2722 ± 72
  1. All compounds were tested using 500 μM ATP and 500 μM Syntide2 as described in Methods. A concentration range from 1 nM to 1 μM for all compounds was used except for CZ25, CZ15 and 1nA-PP1 (2 nM to 2 μM), CZ27 (4 nM to 4 μM) and JC022 (8 nM to 8 μM).