Regional genome transcriptional response of adult mouse brain to hypoxia

BMC Genomics

Table 1 Signaling pathways significantly associated with commonly up-regulated genes in all the forebrain regions after HP.

Level	Signal Classification	Pathway	P value	Molecules*
System level	Hormone	Glucocorticoid Receptor Signaling	0.006	NFKBIA, FKBP5, CDKN1A, TSC22D3, SGK1
	Hypoxia signaling	Hypoxia signaling (Cardiovascular System)	0.016	NFKBIA, VEGFA
Tissue level	Synapses	Clathrin-mediated Endocytosis	0.076	VEGFA, AP2A2
	Development	Axonal Guidance/Ephrin Receptor Signal	0.093	VEGFA, GNA13
Cell level	Growth factors	Insulin/IGF-1 Receptor Signaling	0.054	PPP1R3C, SGK1, CYR61
		Neuregulin/EGF Signaling	0.028	ERRFI1, TMEFF2
	Survival regulation	VDR/RXR Activation	0.023	KLF4, CDKN1A
		p53 Signaling	0.026	CDKN1A, TP53INP1
	Kinase cascade	PI3K/AKT Signaling	0.046	NFKBIA, CDKN1A
		ERK/MAPK Signaling	0.016	H3F3B, PPP1R3C, H3F3A

The significance was determined by Fisher's exact test(P<0.1). Pathways with the same gene hits or with closely related genes were combined. The significance of the combined pathway was determined by the smallest P value available before the combining.* Details of the genes can be found in Additional file 2 Table S2.

ISSN: 1471-2164