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Table 2 Enriched networks at different time points of MDV infection in different chicken lines

From: Temporal transcriptome changes induced by MDV in marek's disease-resistant and -susceptible inbred chickens

Lines

Time

points

Score

Focus

Molecules

Top Functions

L63

5dpi

46

29

Digestive System Development and Function, Hepatic System

Development and Function, Organ Development

  

36

25

Skeletal and Muscular System Development and Function, Tissue

Morphology, Lipid Metabolism

  

35

25

Amino Acid Metabolism, Small Molecule Biochemistry, Cellular

Compromise

  

28

21

Carbohydrate Metabolism, Lipid Metabolism, Small Molecule

Biochemistry

  

24

20

Drug Metabolism, Endocrine System Development and Function, Lipid

Metabolism

 

10dpi

36

25

Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral

Metabolism

  

30

21

Infection Mechanism, Visual System Development and Function,

Dermatological Diseases and Conditions

  

30

21

Molecular Transport, Cellular Movement, Cell Cycle

  

27

22

Neurological Disease, Carbohydrate Metabolism, Lipid Metabolism

  

26

19

Organismal Injury and Abnormalities, Infection Mechanism, Infectious

Disease

 

21dpi

39

28

Cell Morphology, Cellular Function and Maintenance, Cell Death

  

34

22

Cardiovascular System Development and Function, Organismal

Development, Tissue Development

  

27

19

Carbohydrate Metabolism, Small Molecule Biochemistry, Cellular

Assembly and Organization

  

24

17

Cell-To-Cell Signaling and Interaction, Cell-mediated Immune

Response, Cellular Development

  

22

16

Lipid Metabolism, Small Molecule Biochemistry, Behavior

L72

10dpi

29

21

Cardiac Arrythmia, Cardiovascular Disease, Genetic Disorder

  

27

22

Cellular Assembly and Organization, Cellular Compromise, Free

Radical Scavenging

  

26

19

Cell-To-Cell Signaling and Interaction, Cellular Growth and

Proliferation, Skeletal and Muscular System Development and Function

  

24

18

Cell Morphology, Connective Tissue Development and Function,

Skeletal and Muscular System Development and Function

  

22

17

Infection Mechanism, Cardiovascular System Development and

Function, Organismal Development

 

21dpi

38

27

Cell Morphology, Connective Tissue Development and Function,

Skeletal and Muscular System Development and Function

  

32

24

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

  

31

24

Embryonic Development, Tissue Development, Cell Cycle

  

31

24

Cell Morphology, Skeletal and Muscular System Development and

Function, Connective Tissue Development and Function

  

23

20

Connective Tissue Disorders, Genetic Disorder, Cellular Assembly and

Organization

RCS- M

5dpi

32

22

Cell Morphology, Cellular Development, Cell Death

  

32

22

Cellular Assembly and Organization, Cell Morphology, Cellular

Development

  

30

21

Cell Morphology, Cellular Development, Skeletal and Muscular System

    

Development and Function

  

28

20

Amino Acid Metabolism, Small Molecule Biochemistry, Drug

Metabolism

  

24

18

Inflammatory Disease, Renal and Urological Disease, Amino Acid

Metabolism

 

10dpi

34

23

Carbohydrate Metabolism, Lipid Metabolism, Small Molecule

Biochemistry

  

31

21

Antigen Presentation, Cell-To-Cell Signaling and Interaction, Cellular

Function and Maintenance

  

29

20

Molecular Transport, Drug Metabolism, Lipid Metabolism

  

21

16

Carbohydrate Metabolism, Drug Metabolism, Small Molecule

Biochemistry

  

20

16

Dermatological Diseases and Conditions, Genetic Disorder,

Immunological Disease

 

21dpi

33

23

Cell Morphology, Cellular Assembly and Organization, Cell-To-Cell

Signaling and Interaction

  

26

19

Connective Tissue Development and Function, Skeletal and Muscular

System Development and Function, Tissue Morphology

  

24

18

Carbohydrate Metabolism, Small Molecule Biochemistry, Organismal

Functions

  

24

23

Cell Death, Gene Expression, Cellular Function and Maintenance

  

23

18

Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry

  1. *The genes input in IPA software were obtained using P < 0.05, |LogFC|>1.5 and FDR<0.5.