Table 3 List of top 50 genes significantly differentially regulated in liver based on fold difference (t-test).
Gene Symbol | 2Way ANOVA P value | Fold Change in Liver Welch t-test | Regulation in LBW | Fold change skeletal tissue, Welch t-test | Regulation in LBW | Fold change in Cords, Welch t-test | Regulation in LBW | Gene name |
|---|---|---|---|---|---|---|---|---|
ELMOD1 | 0.011425177 | 25.931845 | down | 1.737314 | down | 2.051013 | up | Homo sapiens ELMO/CED-12 domain containing 1 (ELMOD1), mRNA [NM_018712] |
RBBP9 | 0.026729036 | 11.012514 | down | 1.47388 | down | 5.131376 | down | Homo sapiens retinoblastoma binding protein 9 (RBBP9), mRNA [NM_006606] |
MMP25 | 0.001325307 | 10.996225 | down | 2.384582 | down | 1.436251 | down | Homo sapiens matrix metallopeptidase 25 (MMP25), mRNA [NM_022468] |
C5orf46 | 0.047762383 | 10.762607 | down | 1.234639 | up | 1.096919 | up | Homo sapiens similar to AVLV472 (MGC23985), mRNA [NM_206966] |
GOLSYN | 2.29E-05 | 6.13113 | up | 1.05566 | up | 1.458383 | up | Homo sapiens hypothetical protein FLJ20366 (FLJ20366), mRNA [NM_017786] |
LCN15 | 0.005291665 | 5.3478875 | up | 1.891747 | up | 2.217465 | up | Homo sapiens MSFL2541 (UNQ2541), mRNA [NM_203347] |
CCDC146 | 0.030661521 | 5.281487 | up | 1.06658 | up | 1.360575 | up | Homo sapiens KIAA1505 protein (KIAA1505), mRNA [NM_020879] |
AK094929 | 0.001118242 | 5.262121 | up | 1.690864 | up | 1.110624 | up | Homo sapiens cDNA FLJ37610 fis, clone BRCOC2011398. [AK094929] |
SORCS3 | 0.00328917 | 5.0026994 | up | 2.266284 | up | 2.921157 | up | Homo sapiens sortilin-related VPS10 domain containing receptor 3 (SORCS3), mRNA [NM_014978] |
COL4A4 | 0.01571377 | 4.897748 | down | 1.548386 | down | 1.059327 | down | Homo sapiens collagen, type IV, alpha 4 (COL4A4), mRNA [NM_000092] |
IL1R2 | 0.004347455 | 4.777918 | down | 1.8715 | down | 1.690538 | down | Homo sapiens interleukin 1 receptor, type II (IL1R2), transcript variant 1, mRNA [NM_004633] |
CD200R1 | 0.04967409 | 4.7169123 | down | 1.052303 | up | 1.319852 | down | Homo sapiens CD200 receptor 1 (CD200R1), transcript variant 1, mRNA [NM_138806] |
GTSF1 | 0.017040279 | 4.653995 | up | 3.663281 | up | 2.487166 | up | Homo sapiens family with sequence similarity 112, member B (FAM112B), mRNA [NM_144594] |
SNAI1 | 0.005038617 | 4.582946 | down | 1.534132 | down | 1.847129 | down | Homo sapiens snail homolog 1 (Drosophila) (SNAI1), mRNA [NM_005985] |
USH1C | 0.00505742 | 4.3276477 | up | 1.595945 | up | 1.465964 | up | Homo sapiens Usher syndrome 1C (autosomal recessive, severe) (USH1C), transcript variant 1, mRNA [NM_005709] |
ALLC | 0.006709512 | 4.060955 | up | 1.861818 | up | 2.766094 | up | Homo sapiens allantoicase (ALLC), transcript variant 1, mRNA [NM_018436] |
CXCL3 | 0.04903758 | 3.9091544 | down | 1.096309 | down | 1.172056 | up | Homo sapiens chemokine (C-X-C motif) ligand 3 (CXCL3), mRNA [NM_002090] |
XR_014204 | 0.029225934 | 3.8491352 | down | 3.167453 | down | 1.084816 | up | PREDICTED: Macaca mulatta hypothetical protein LOC719546 (LOC719546), mRNA [XR_014204] |
XR_011794 | 0.010519872 | 3.637105 | up | 3.785519 | up | 2.76764 | up | PREDICTED: Macaca mulatta similar to poly(A)-specific ribonuclease (PARN)-like domain containing 1 (LOC707835), mRNA [XR_011794] |
NMNAT2 | 0.045685206 | 3.6255727 | up | 2.521069 | down | 2.189285 | up | Homo sapiens nicotinamide nucleotide adenylyltransferase 2 (NMNAT2), transcript variant 1, mRNA [NM_015039] |
SLC39A8 | 0.041505713 | 3.6139402 | down | 1.366996 | down | 1.390711 | down | Homo sapiens solute carrier family 39 (zinc transporter), member 8 (SLC39A8), mRNA [NM_022154] |
CA2 | 0.033340864 | 3.4830022 | down | 3.573662 | down | 1.194329 | up | Homo sapiens carbonic anhydrase II (CA2), mRNA [NM_000067] |
NTRK3 | 0.003890598 | 3.4711208 | up | 1.593136 | up | 1.043792 | down | Homo sapiens neurotrophic tyrosine kinase, receptor, type 3 (NTRK3), transcript variant 1, mRNA [NM_001012338] |
C17orf75 | 0.001362531 | 3.4477015 | down | 3.758336 | down | 1.443745 | down | Homo sapiens chromosome 17 open reading frame 75 (C17orf75), mRNA [NM_022344] |
CXCL1 | 0.006956845 | 3.392382 | down | 1.063934 | up | 4.611126 | down | Homo sapiens chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1), mRNA [NM_001511] |
NM_198692 | 0.03194352 | 3.3605232 | down | 1.343767 | up | 1.654617 | down | Homo sapiens keratin associated protein 10-11 (KRTAP10-11), mRNA. [NM_198692] |
SHANK2 | 0.023280138 | 3.3547363 | up | 1.255762 | up | 1.189415 | down | Homo sapiens SH3 and multiple ankyrin repeat domains 2 (SHANK2), transcript variant 1, mRNA [NM_012309] |
CCDC81 | 0.004982437 | 3.2717588 | down | 1.533572 | down | 4.912844 | down | Homo sapiens coiled-coil domain containing 81 (CCDC81), mRNA [NM_021827] |
CCL11 | 0.008992519 | 3.1781478 | down | 4.050988 | down | 1.002582 | up | Homo sapiens chemokine (C-C motif) ligand 11 (CCL11), mRNA [NM_002986] |
CO647386 | 0.020776557 | 3.1651435 | down | 1.030158 | down | 1.631509 | down | ILLUMIGEN_MCQ_40418 Katze_MMPB2 Macaca mulatta cDNA clone IBIUW:21432 5' similar to Bases 185 to 778 highly similar to human CXCL2 (Hs.75765), mRNA sequence [CO647386] |
GPR98 | 0.024752488 | 3.1570897 | down | 1.10821 | down | 3.919889 | down | Homo sapiens G protein-coupled receptor 98 (GPR98), transcript variant 1, mRNA [NM_032119] |
TMEM59L | 5.34E-04 | 3.137047 | up | 1.57364 | up | 1.407988 | up | Homo sapiens transmembrane protein 59-like (TMEM59L), mRNA [NM_012109] |
UGT1A6 | 0.040070046 | 3.1353552 | down | 2.066639 | down | 1.399845 | down | Homo sapiens UDP glucuronosyltransferase 1 family, polypeptide A6 (UGT1A6), transcript variant 1, mRNA [NM_001072] |
KCNE2 | 7.02E-04 | 3.1135461 | up | 1.972823 | up | 1.170852 | down | Homo sapiens potassium voltage-gated channel, Isk-related family, member 2 (KCNE2), mRNA [NM_172201] |
XR_012376 | 0.022554293 | 3.0699794 | down | 1.9303 | down | 1.439485 | down | PREDICTED: Macaca mulatta hypothetical protein LOC710335 (LOC710335), mRNA [XR_012376] |
RXFP1 | 0.002097808 | 3.0400152 | up | 1.931833 | up | 1.276558 | up | Homo sapiens relaxin/insulin-like family peptide receptor 1 (RXFP1), mRNA [NM_021634] |
ITGBL1 | 0.02861261 | 3.0041916 | down | 2.563332 | down | 1.243521 | down | Homo sapiens integrin, beta-like 1 (with EGF-like repeat domains) (ITGBL1), mRNA [NM_004791] |
PASK | 0.03426426 | 2.995584 | up | 5.977056 | up | 19.17474 | up | Homo sapiens PAS domain containing serine/threonine kinase (PASK), mRNA [NM_015148] |
DEFB1 | 0.004949556 | 2.9797235 | down | 1.065357 | up | 2.807533 | down | Homo sapiens defensin, beta 1 (DEFB1), mRNA [NM_005218] |
WDR8 | 0.004681234 | 2.9781044 | down | 5.68043 | down | 8.061375 | down | Homo sapiens WD repeat domain 8 (WDR8), mRNA [NM_017818] |
RIMS4 | 0.04112827 | 2.9677074 | up | 1.724443 | up | 1.024011 | down | Homo sapiens regulating synaptic membrane exocytosis 4 (RIMS4), mRNA [NM_182970] |
PDGFRL | 0.011396675 | 2.9371088 | down | 1.21306 | down | 1.55284 | down | Homo sapiens platelet-derived growth factor receptor-like (PDGFRL), mRNA [NM_006207] |
TNRC4 | 0.005930619 | 2.9251838 | up | 1.208589 | up | 1.396738 | up | Homo sapiens trinucleotide repeat containing 4 (TNRC4), mRNA [NM_007185] |
UGT2B11 | 0.02518766 | 2.9193914 | down | 1.09908 | down | 2.958316 | down | Homo sapiens UDP glucuronosyltransferase 2 family, polypeptide B11 (UGT2B11), mRNA [NM_001073] |
FLT3LG | 0.029793594 | 2.8908129 | up | 1.037797 | down | 1.527226 | up | Homo sapiens fms-related tyrosine kinase 3 ligand (FLT3LG), mRNA [NM_001459] |
IP6K3 | 0.03900314 | 2.8685477 | up | 1.471319 | up | 1.39455 | down | Homo sapiens inositol hexaphosphate kinase 3 (IHPK3), mRNA [NM_054111] |
ST6GALNAC1 | 0.03669531 | 2.8622296 | down | 1.408642 | down | 2.126189 | down | Homo sapiens ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 (ST6GALNAC1), mRNA [NM_018414] |
EFNA4 | 0.007086268 | 2.843187 | down | 1.084758 | up | 2.766163 | down | Homo sapiens ephrin-A4 (EFNA4), transcript variant 1, mRNA [NM_005227] |
MYST3 | 0.013409907 | 2.827006 | up | 3.302978 | up | 1.403819 | up | Homo sapiens MYST histone acetyltransferase (monocytic leukemia) 3 (MYST3), mRNA [NM_006766] |
XM_370715 | 0.001614059 | 2.7565975 | up | 1.561267 | up | 2.382949 | up | PREDICTED: Homo sapiens similar to hypothetical protein MGC48915 (LOC387911), mRNA [XM_370715] |
NM_031436 | 0.035783853 | 2.6903787 | up | 1.740635 | up | 1.698687 | up | Homo sapiens aldo-keto reductase family 1, member C-like 2 (AKR1CL2), mRNA. [NM_031436] |