Recent human evolution has shaped geographical differences in susceptibility to disease

BMC Genomics

Table 2 Summary of multiple regression analysis for the Continental Set.

a) FULL SET	F_df:1,31	P value	R²	Beta	P value	Tol^c
a.1) Two predictors (n = 33)^a
Gene Length (number of SNPs)	24.641	5 × 10 ^-7	0.596	0.613	7 × 10 ^-6	>0.93
F_ST (population differentiation)				0.456	0.00033	>0.99
a.2) One predictor (n = 31;NRG1/PARK2 out)
F_ST (population differentiation)	16.097	0.00039	0.335	0.597	0.00039	-
b) CONSERVATIVE SET ^b	F _df:1,24	P value	R²	Beta	P value	Tol^c
b.1) Two predictors (n = 26)^a
F_ST (population differentiation)	26.709	9.9 × 10 ^-7	0.673	0.64	1.1 × 10 ^-5	>0.99
Gene Length (number of SNPs)				0.502	2.14 × 10 ^-4	>0.99
b.2) One predictor (n = 24;NRG1/PARK2 out)
F_ST (population differentiation)	18.023	0.00031	0.428	0.673	0.000314	-

^a 6 Excluded non-significant variables: a) percentage of intronic SNPs in the gene from each association, b) total number of studies of each association, c) total number of studies performed in Europe, d) total number of studies performed in East Asia, e) average study sample size of each association, and f) average year of study performance in each association
^b Conservative set contains those associations that at least in one continent have a replicability index of 50%
^c Tol = Tolerance

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