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Table 3 Population-specific test on the long-term evolutionary status for the SNPs from the 890 associations from the Global Set.

From: Recent human evolution has shaped geographical differences in susceptibility to disease

  Europeans (CEU)a East Asians (CHB)a East Asians (JPT)a Africans (YRI)a
Replicability ANCb(%) DERb(%) ANCb(%) DERb(%) ANCb(%) DERb(%) ANCb(%) DERb(%)
≤66.67% 19017 4533 18529 4991 18623 4919 19816 3757
(n = 441) (80.8) (19.2) (78.8) (21.2) (79.1) (20.9) (84.1) (15.9)
≥66.67% 19783 5173 19271 5620 19334 5556 20789 4187
(n = 441) (79.3) (20.7) (77.4) (22.6) (77.7) (22.3) (83.2) (16.8)
  p-value 4.89 × 10 -5 p-value 3.19 × 10 -4 p-value 1.43 × 10 -4 p-value 0.0144
  1. a CEU = North Americans (Utah) of Northern European ancestry; CHB = Chinese from Beijing; JPT = Japanese from Tokyo; YRI = Yorubans from Ibadan (Nigeria)
  2. b ANC = SNPs with an ancestral major allele (freq ≥ 0.5); DER = SNPs with a derived major allele (freq ≥ 0.5)