CHD subnetwork and representative modules. (A) CHD subnetwork extracted from the weighted PPI network. Different colors represent different modules. All the modules with size smaller than 10 are in the same green color. (B) Pie chart of module size, where modules with size smaller than 10 are grouped into category "others". (C-E) Three representative modules. Dark red diamonds represent putative disease genes, and red rectangles represent final candidate genes identified by our method.