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Table 1 Module information.

From: Identification of dysfunctional modules and disease genes in congenital heart disease by a network-based approach

Module

Size

Interaction

Score

Mutual Information (empirical p-value)

Correlation (p-value)

CHD genes in this module

M1

25

2.94E-01

2.80E-02

1.80E-03

GATA6

M2

66

4.33E-01

8.00E-03

3.62E-03

ELN

M3

61

2.83E-01

2.00E-03

9.82E-01

ACVR2B

M4

14

8.50E-02

2.70E-02

7.02E-02

MYH11

M5

46

1.47E-01

2.00E-03

1.67E-02

MYH7

M6

27

4.23E-01

1.80E-02

3.36E-03

CITED2

M7

28

3.44E-01

8.39E-01

5.76E-01

FLNA

M8

40

2.25E-01

<1.00E-06

3.66E-02

MYBPC3

M9

18

9.94E-02

7.40E-02

1.02E-02

GATA4, TBX5

M10

64

5.75E-01

<1.00E-06

8.95E-03

ACTC1

M11

41

4.32E-01

2.30E-02

4.80E-01

NKX2-5

M12

46

4.51E-01

2.00E-03

1.81E-05

NOTCH1, JAG1

  1. Size means the number of genes in each module. Interaction score evaluates the topological relations between modules. Hub modules have higher scores while peripheral modules have lower scores. Mutual Information evaluates the significance of synergistic differential expression within a module compared with 1000 random gene sets of the same size. Correlation measures the significance of correlation coexpression of two interacting partners within a module compared with 1000 random edge lists of the same number.
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BMC Genomics

ISSN: 1471-2164

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