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Table 1 Module information.

From: Identification of dysfunctional modules and disease genes in congenital heart disease by a network-based approach

Module Size Interaction
Score
Mutual Information (empirical p-value) Correlation (p-value) CHD genes in this module
M1 25 2.94E-01 2.80E-02 1.80E-03 GATA6
M2 66 4.33E-01 8.00E-03 3.62E-03 ELN
M3 61 2.83E-01 2.00E-03 9.82E-01 ACVR2B
M4 14 8.50E-02 2.70E-02 7.02E-02 MYH11
M5 46 1.47E-01 2.00E-03 1.67E-02 MYH7
M6 27 4.23E-01 1.80E-02 3.36E-03 CITED2
M7 28 3.44E-01 8.39E-01 5.76E-01 FLNA
M8 40 2.25E-01 <1.00E-06 3.66E-02 MYBPC3
M9 18 9.94E-02 7.40E-02 1.02E-02 GATA4, TBX5
M10 64 5.75E-01 <1.00E-06 8.95E-03 ACTC1
M11 41 4.32E-01 2.30E-02 4.80E-01 NKX2-5
M12 46 4.51E-01 2.00E-03 1.81E-05 NOTCH1, JAG1
  1. Size means the number of genes in each module. Interaction score evaluates the topological relations between modules. Hub modules have higher scores while peripheral modules have lower scores. Mutual Information evaluates the significance of synergistic differential expression within a module compared with 1000 random gene sets of the same size. Correlation measures the significance of correlation coexpression of two interacting partners within a module compared with 1000 random edge lists of the same number.