PNAC: a protein nucleolar association classifier

BMC Genomics

Table 2 Tests of accuracy

Class	Priors	Counts			Sensitivity^d			PPV^e
		Test set 1^a	Test set 2^b	Test set 3^c	Test set 1	Test set 2	Test set 3	Test set 1	Test set 2	Test set 3
Nucleolar-enriched	0.20	30	15	52	0.72	0.78	0.56	0.68	0.61	0.47
Nucleolar-nucleoplasmic	0.15	22	7	24	0.73	0.57	0.50	0.63	0.60	0.41
Nucleolar-cytoplasmic	0.15	24	16	63	0.77	0.69	0.59	0.70	0.74	0.53
Non-nucleolar	0.50	200	100	344	0.90	0.91	0.81	0.94	0.93	0.87

^a Test set 1: leave-one-out cross-validation test
^b Test set 2: independent literature-based test
^c Test set 3: SILAC experimental independent test
^d These sensitivity measures represent average sensitivity values over ten runs. Their standard deviations were all below 0.03.
^e PPV: positive predictive value. These measures represent average PPV values over ten runs. Their standard deviations were all below 0.1.

ISSN: 1471-2164