Enrichment of association signal (p < 0.01) around the gene for seven diseases genotyped by the WTCCC. The percentage of SNPs with p < 0.01 (red circles) is plotted for their distance to the closest gene. Values have been smoothed using a 50 kb sliding window (blue line). The light blue area represents the distribution expected by chance (95% confidence intervals) based on 100,000 permutations of the case/control status. The purple triangle represents the proportion of SNPs with p < 0.01 in coding exons.