Figure 2

Distribution of RLEs in inhibitory network. (a) Dot plots of enzyme counts for each pathway from four following aspects for Human, Mouse, Rat, budding Yeast and E. coli. The statistic counts for certain pathways of an organism are grouped in each cell. In each cell, MEs (Provider) mean count of all metabolic enzymes which produce inhibitors, RLEs (Provider) mean count of RLEs which produce inhibitors, Targets by MEs (Provider) mean count of inhibited enzymes by all the metabolic enzymes, Targets by RLEs (Provider) mean count of inhibited enzymes by RLEs. The above percentage in each cell is the ratio between the first line and the second line meaning the fraction of the RLEs (Provider) to all metabolic enzymes (Provider); the bottom percentage is the ratio between the third line and the fourth line meaning the fraction of Targets by the RLEs (Provider) to those by all metabolic enzymes (Provider). (b) Colour grid for fraction of the inhibited RLEs to all inhibited metabolic enzymes for each pathway in five model species. The inhibited targets are enriched in RLEs are red-marked (hypergeometric tests, p value <0.05). (c) Colour grid for fraction of the inhibited RLEs by RLEs to inhibited RLEs by all the metabolic enzymes in each pathway from five model species. Hypergeometric tests reveal that all the inhibited RLEs are preferred inhibited by RLEs except one blue-marked (p value < 0.05).