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Table 2 Selected GO terms and selected genes illustrating the functional categories enriched in the clusters of discriminative genes derived using ECD (Figure 7). Several representative gene symbols are indicated in parentheses.

From: A robust tool for discriminative analysis and feature selection in paired samples impacts the identification of the genes essential for reprogramming lung tissue to adenocarcinoma

Cluster 1
•Inflammatory response [AGER, ALOX5, MYD88, SEPP1, SERPING1]
•Regulation of cytoskeleton organization [ABLIM1, DES, DST, NEDD9, PALLD, PRF1]
•Positive regulation of response to stimulus [C1QA, C1QB, C7, CADM1, CX3CL1, FABP4, FCER1G, MYD88, SERPING1, SLIT2]
•Wound healing [CD36, GNAQ, HBEGF, MYH10, SERPING1, THBD, VWF]
•Response to mechanical stimulus [BTG2,TIM2, CAV1,CCL2, MGP,TXNIP,TGFBR2, FOS]
•Negative regulation of cell proliferation [SFTPD, VSIG4]
•Regulation of locomotion [EGFL7,CLIC4,AGER, DLC1,ENPP2,EDN1, IL6, IL6ST, VCL]
•Complement activation [C1QA, C1QB, C7, SERPING1]
•Positive regulation of immune response [C1QA, C1QB, C7, CADM1, FCER1G, MYD88, SERPING1]
•Hormonal immune response[C1QA, C1QB, C7, CCL2, IL6, SERPING1] 1, FCER1G, MYD88, SERPING1]
Cluster 2
•M phase of mitotic cell cycle [AURKA, BIRC5, BUB1,CCNB1, CENPE]
•Negative regulation of intracellular transport [BARD1, GSK3B, NCBP2, NF1, TACC3]
•Microtubule-based process [CEP250, DST]
•Response to DNA damage stimulus [CSNK1D, DDB1, NONO,POLD1, TOP2A]
•Spindle organization [AURKA, BUB1B, CKS2, TTK, TUBG1, ZWINT]
•Cellular protein localization [AP1B1, ARF5, ICMT, NUP62, TIMM13, TOM1L1]
•DNA repair [APEX1, CSNK1D, DDB1, HMGB2,PARP1,POLB, POLD1,TOP2A]
•Glycosylation[ALG6,FUT2,GALNT10,MGAT4B, OGT, STT3A, UGCGL1]
Cluster 3
•Enzyme linked receptor protein signaling pathway [ADRB2, ARRB2,SPTBN1, TEK, TGFBR3, ZFP106]
•Metal ion homeostasis [AGTR1, C5AR1, RGN, S1PR4, TRPC6]
•Protein amino acid phosphorylation [AATK, ADRB2, TIE1, TTN, ULK2]
•Transmembrane receptor protein tyrosine kinase signaling pathway [ADRB2, CRYAB, SORBS1, TEK, ZFP106]
•Negative regulation of cell proliferation [ADAMTS8, AIF1, TENC1, TGFB1I1, TOB2]
Cluster 4
•Collagen fibril organization [COL3A1, COL5A2]
•Glycolysis[ALDOA, ENO1, GAPDH, PKM2, TPI1]
•Carbohydrate catabolic process [ALDOA, ENO1, FUCA1, GAPDH, TPI1]
•Extracellular structure organization [AGRN, COL11A1, COL3A1, COL5A2, ERBB2]
•Collagen metabolic process [COL3A1, MMP1, MMP11, MMP7]
•Negative regulation of cell adhesion [CDKN2A, HNRNPAB, TGFBI]
•Generation of precursor metabolites and energy [ALDOA, ENO1, GAPDH, UQCRH, UQCRQ]
•Negative regulation of protein ubiquitination [PSMA1,PSMA2, PSMB2, PSMB3, PSMB4, PSMB5]