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Table 3 Enriched UP_SEQ Features terms in common and unique sub-sets of PT-AT ECD-derived signature and Lung AC Meta-signature

From: A robust tool for discriminative analysis and feature selection in paired samples impacts the identification of the genes essential for reprogramming lung tissue to adenocarcinoma

UP_SEQ_FEATURE Count % P-Value Fold enrichment Benjamini FDR
Common sub-set
nucleotide phosphate-binding region:ATP 59 13.3 1.60E-11 2.7 2.60E-08 2.70E-08
mutagenesis site 95 21.5 2.90E-11 2 2.40E-08 4.90E-08
binding site: ATP 36 8.1 4.20E-08 2.9 2.30E-05 7.00E-05
domain: kinesin-motor 9 2 5.20E-06 9.1 2.10E-03 8.70E-03
signal peptide 112 25.3 5.80E-06 1.5 1.90E-03 9.80E-03
domain: MCM 5 1.1 1.80E-05 27.1 4.80E-03 3.00E-02
sequence variant 317 71.7 2.30E-05 1.1 5.30E-03 3.80E-02
domain: protein kinase 27 6.1 3.50E-05 2.5 7.10E-03 5.90E-02
active site: proton acceptor 33 7.5 5.80E-05 2.2 1.00E-02 9.70E-02
Discriminative signature: 2829 probes; unique 1862
mutagenesis site 271 15.4 3.70E-11 1.5 1.70E-07 6.90E-08
cross-link: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) 38 2.2 2.00E-05 2.1 4.40E-02 3.70E-02
binding site:substrate 50 2.8 2.90E-05 1.9 4.30E-02 5.40E-02
Meta-signature: 1249 probes; unique 806
domain: protein kinase 66 8.3 4.00E-18 3.4 9.90E-15 7.00E-15
nucleotide phosphate-binding region: ATP 99 12.4 3.20E-17 2.5 4.00E-14 5.70E-14
binding site: ATP 69 8.7 1.20E-16 3.1 9.20E-14 2.00E-13
mutagenesis site 160 20.1 6.90E-16 1.9 4.20E-13 1.20E-12
active site: proton acceptor 71 8.9 2.60E-13 2.6 1.30E-10 4.60E-10
nucleotide phosphate-binding region: GTP 28 3.5 9.10E-05 2.3 3.70E-02 1.60E-01