Table 3 Enriched UP_SEQ Features terms in common and unique sub-sets of PT-AT ECD-derived signature and Lung AC Meta-signature

Common sub-set

nucleotide phosphate-binding region:ATP

59

13.3

1.60E-11

2.7

2.60E-08

2.70E-08

mutagenesis site

95

21.5

2.90E-11

2

2.40E-08

4.90E-08

binding site: ATP

36

8.1

4.20E-08

2.9

2.30E-05

7.00E-05

domain: kinesin-motor

9

2

5.20E-06

9.1

2.10E-03

8.70E-03

signal peptide

112

25.3

5.80E-06

1.5

1.90E-03

9.80E-03

domain: MCM

5

1.1

1.80E-05

27.1

4.80E-03

3.00E-02

sequence variant

317

71.7

2.30E-05

1.1

5.30E-03

3.80E-02

domain: protein kinase

27

6.1

3.50E-05

2.5

7.10E-03

5.90E-02

active site: proton acceptor

33

7.5

5.80E-05

2.2

1.00E-02

9.70E-02

Discriminative signature: 2829 probes; unique 1862

mutagenesis site

271

15.4

3.70E-11

1.5

1.70E-07

6.90E-08

cross-link: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

38

2.2

2.00E-05

2.1

4.40E-02

3.70E-02

binding site:substrate

50

2.8

2.90E-05

1.9

4.30E-02

5.40E-02

Meta-signature: 1249 probes; unique 806

domain: protein kinase

66

8.3

4.00E-18

3.4

9.90E-15

7.00E-15

nucleotide phosphate-binding region: ATP

99

12.4

3.20E-17

2.5

4.00E-14

5.70E-14

binding site: ATP

69

8.7

1.20E-16

3.1

9.20E-14

2.00E-13

mutagenesis site

160

20.1

6.90E-16

1.9

4.20E-13

1.20E-12

active site: proton acceptor

71

8.9

2.60E-13

2.6

1.30E-10

4.60E-10

nucleotide phosphate-binding region: GTP

28

3.5

9.10E-05

2.3

3.70E-02

1.60E-01