Figure 5

Format of ADR vs. drug target facts and an example of drug target expanding network. a) This figure shows the format of ADR vs. drug target facts. D _n , S _i , and T _j mean drug n, ADR i, and target j respectively. b) This figure is an example of a drug target expanding network. The dotted lines mean PPIs. c) This part illustrates the process of the drug target expanding one level in PPI network. T ₁ , T ₂ , and T ₅ are present twice in all branches of this expanding "tree", thus the values in cells DT ₁₁ , DT ₁₂ , and DT ₁₅ in ADR vs. drug target facts are all 2; the rest, including DT ₁₃ and DT ₁₄ , are both 1.