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Table 6 Multi-species derived nerodegenerative signature can pick out neuroprotective drugs in CMAP.

From: A searchable cross-platform gene expression database reveals connections between drug treatments and disease

COMPOUND

< r >

prob

N

verteporfin

-0.48

0.007

3

lysergol

-0.43

0.021

4

N-acetyl-L-leucine

-0.41

0.003

4

chrysin

-0.41

0.004

3

pipenzolate bromide

-0.40

0.033

4

milrinone

-0.40

0.030

3

apigenin

-0.39

0.017

4

carbachol

-0.38

0.006

4

camptothecin

-0.38

0.002

3

chlorzoxazone

-0.37

0.006

4

amiodarone

-0.35

0.002

5

luteolin

-0.35

0.008

4

torasemide

-0.35

0.020

4

pridinol

-0.35

0.004

4

H-7

-0.34

0.002

4

nialamide

-0.34

0.047

4

GW-8510

-0.34

0.003

4

trifluridine

-0.34

0.017

4

galantamine

-0.34

0.010

4

metacycline

-0.32

0.046

4

harmine

-0.31

0.016

4

nomifensine

-0.31

0.023

5

  1. The connectivity map hits for the neurodegeneration signature are given. The correlation <r > is the average over the drug replicates and the significance is measured with the Student's t-test. Drugs with established neuroprotective activity are highlighted in bold.