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Table 4 The 50 PFAM categories most expanded in the Mycobacteria relative to the non- Mycobacteria

From: Comparative analysis of mycobacterium and related actinomycetes yields insight into the evolution of mycobacterium tuberculosis pathogenesis

PFAM descriptor PFAM ID p-valuea inter-to-intra centroid difference
e Protein of unknown function (DUF2599) PF10783 1.50E-10 8.80E+00
c Cutinase PF01083 1.60E-10 1.50E+01
e Uncharacterized protein conserved in bacteria (DUF2236) PF09995 2.20E-10 1.60E+01
c Lpp-LpqN Probable lipoprotein LpqN PF10738 4.70E-10 1.30E+01
e Domain of unknown function (DUF385) PF04075 5.70E-10 1.30E+01
b Domain of unk function DUF140 (yrbE genes in mce operons) PF02405 1.60E-09 1.40E+01
Retinal pigment epithelial membrane protein PF03055 8.50E-09 1.40E+01
e Domain of unknown function (DUF427) PF04248 1.40E-08 1.60E+01
ABC transporter transmembrane region 2 PF06472 PF06472 1.80E-08 1.10E+01
b Peroxidase (katG-isoniazid resistance) PF00141 4.10E-08 1.20E+01
b mce related protein PF02470 1.30E-07 1.30E+01
N O-methyltransferase N-terminus PF02409 1.70E-07 1.70E+01
Activator of Hsp90 ATPase homolog 1-like protein PF08327 2.40E-07 1.10E+01
Coronavirus nonstructural protein NS1 PF06145 3.00E-07 1.20E+01
e Predicted integral membrane protein (DUF2189) PF09955 3.10E-07 1.40E+01
e Uncharacterized protein family (UPF0089) PF03007 3.80E-07 1.50E+01
b Acetyltransf 2 N-acetyltransferase (inactivates isoniazid) PF00797 3.90E-07 1.70E+01
e Domain of unknown function (DUF1957) PF09210 5.50E-07 7.90E+00
KRAB box PF01352 7.00E-07 1.70E+01
Prokaryotic acetaldehyde dehydrogenase, dimerisation PF09290 8.10E-07 9.00E+00
DmpG-like communication domain PF07836 9.50E-07 1.10E+01
Nuclear transport factor 2 (NTF2) domain PF02136 1.00E-06 1.30E+01
Wyosine base formation PF08608 1.10E-06 1.40E+01
AIG2-like family PF06094 1.30E-06 1.80E+01
e Protein of unknown function (DUF867) PF05908 1.30E-06 1.50E+01
Phage-related minor tail protein PF10145 2.10E-06 1.20E+01
c Fatty acid desaturase PF03405 2.30E-06 1.00E+01
PaaX-like protein PF07848 2.80E-06 1.50E+01
Adenylate and Guanylate cyclase catalytic domain PF00211 3.70E-06 1.10E+01
Fibronectin-attachment protein (FAP) PF07174 3.80E-06 1.30E+01
Leucine Rich Repeat PF07723 5.50E-06 1.10E+01
2-nitropropane dioxygenase PF03060 5.70E-06 1.40E+01
c Fatty acid desaturase PF00487 7.90E-06 1.30E+01
e Protein of unknown function (DUF732) PF05305 9.10E-06 1.50E+01
c Enoyl-CoA hydratase/isomerase family PF00378 9.70E-06 1.10E+01
arg-2/CPA1 leader peptide PF08252 1.00E-05 1.40E+01
c alpha/beta hydrolase fold (lipases) PF07859 1.10E-05 1.50E+01
Cytochrome P450 PF00067 1.40E-05 1.20E+01
c Cyclopropane-fatty-acyl-phospholipid synthase PF02353 PF02353 1.60E-05 1.20E+01
Isoprenylcysteine carboxyl methyltransferase (ICMT) family PF04140 1.90E-05 1.50E+01
Hydratase/decarboxylase PF01689 2.50E-05 6.60E+00
PsbJ PF01788 3.00E-05 9.40E+00
Linocin M18 bacteriocin protein PF04454 3.40E-05 1.60E+01
Extensin-like protein repeat PF02095 4.00E-05 1.50E+01
5HT transporter Serotonin (5-HT) neurotransmitter transporter, N-terminus PF03491 4.00E-05 9.50E+00
e Protein of unknown function (DUF571) PF04600 4.20E-05 7.70E+00
Tryptophyllin-3 skin active peptide PF08248 4.90E-05 1.50E+01
AMP-binding enzyme PF00501 8.10E-05 9.20E+00
e Bacterial protein of unknown function (DUF853) PF05872 9.90E-05 1.30E+01
c Acyl-ACP thioesterase PF01643 1.10E-04 1.10E+01
  1. aBonferroni-corrected p-value calculated from T-test
  2. b pathogenicity or survival within the host
  3. c Lipid metabolism
  4. d Cofactor biosynthesis
  5. e unknown function