Figure 3

Funshift analysis of CIR sub-families A and B. Significant rate shifting sites (RSS, defined as U values greater than 4) and conservation shifting sites (CSS, defined as Z scores greater than 0.5) are plotted along the CIR alignment, A). The sequences of 5 representative CIR sub-family A and B members are shown, B), with the most significantly shifting sites highlighted as follows: U values greater than 15 are shown in yellow for sub-family A and green for sub-family B members; Z scores greater than 2 are shown in pink for sub-family A and blue for sub-family B members. The most significantly shifting sites, (as defined in B), are listed in Table 1.