Table 1 Highly significant rate and conservation shifting sites identified between the two major CIR sub-families

G W S R H Y I N L Q D

K

2.24

I

L

2.09

I V L F S

Y

2.95

C S W K L F Y I Q

F L I N

2.60

C

N K S G D

2.49

K

S L F

2.62

I A V T S M N Y K H L

C F R Y L

2.09

Y E R G V K A I R

P S A L T

2.50

L

S

2.74

S T K A L V P Y F I

L

2.21

W R Q S I G C

F

2.79

R T K G A V N

D G H

2.09

K E M N T Y

R

2.15

K E F T N I

Q H K R N

2.44

K

Q

2.21

K

Y

2.36

M

R

2.93

I

K

2.90

N

K

2.42

L

T A I K V

2.01

U value

M

M D K T N I L

19.66

V N K G A

T Y D V S E K N Q P G I

16.86

E K T A S Q P I S D R L Y G N

E P F L T

19.99

I Q D E N P A S G H L K V T R

S E D G Q R

29.63

I P S V T N A K E Q L C Y H G

S F N T P L

45.64

I V L D

L R V I P

18.26