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Table 1 Highly significant rate and conservation shifting sites identified between the two major CIR sub-families

From: Characterization and gene expression analysis of the cir multi-gene family of plasmodium chabaudi chabaudi (AS)

Position in alignment Residues in CIR sub-family:  
  A B  
Significant conservation shifting sites (CSS):   Z score
145 G W S R H Y I N L Q D K 2.24
172 I L 2.09
176 I V L F S Y 2.95
196 C S W K L F Y I Q F L I N 2.60
210 C N K S G D 2.49
221 K S L F 2.62
233 I A V T S M N Y K H L C F R Y L 2.09
330 Y E R G V K A I R P S A L T 2.50
349 L S 2.74
350 S T K A L V P Y F I L 2.21
353 W R Q S I G C F 2.79
354 R T K G A V N D G H 2.09
356 K E M N T Y R 2.15
358 K E F T N I Q H K R N 2.44
360 K Q 2.21
361 K Y 2.36
363 M R 2.93
367 I K 2.90
368 N K 2.42
369 L T A I K V 2.01
Significant rate shifting sites (RSS):   U value
8 M M D K T N I L 19.66
25 V N K G A T Y D V S E K N Q P G I 16.86
315 E K T A S Q P I S D R L Y G N E P F L T 19.99
316 I Q D E N P A S G H L K V T R S E D G Q R 29.63
322 I P S V T N A K E Q L C Y H G S F N T P L 45.64
366 I V L D L R V I P 18.26
  1. The most significant CSS (Z > 2) and RSS (U > 15) are listed, with the possible amino acids for each of the two sub-families at each position of the alignment. × refers to the IUPAC code, representing any amino acid.