Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes

Table 6 GO clustering analysis of downregulated genes in Manf^Δ96 larval mutants

	GO term	enrichment score	gene number
1	nuclear lumen, intracellular organelle lumen	3.9	50
2	ncRNA, rRNA metabolic process	3.7	23
3	chromosome, non-membrane-bounded organelle	3.7	72
4	DNA replication, DNA metabolic process	3.4	29
5	prolyl 4-hydroxylase, oxioreductase, ER part	3.4	24
6	RNA, mRNA metabolic process, spliceosome	2.8	45
...	mRNA transport, nuclear transport, nuclear export	1.6	14
...	chromosome condensation, DNA packaging	1.6	15
...	cell cycle, mitosis, chromosome segregation	1.3	59

Clusters are represented starting from the highest enrichment score in diminishing order. Only the highest clusters are shown, for the full list of DAVID cluster analysis of downregulated genes in Manf^Δ96 mutants, see Additional file 4. In the case on missing order number replaced by "..." there were several clusters higher in order describing similar processes that have been listed already above.

ISSN: 1471-2164