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Table 9 List of genes with altered expression according to microarray analysis related to endocytosis KEGG pathway

From: Gene expression analysis of Drosophilaa Manf mutants reveals perturbations in membrane traffic and major metabolic changes

KEGG

Gene

embryo

larvae

 

name

name

o.ex.

mut.

o.ex.

mut.

description

RTK

htl

   

down

Fgf receptor

RTK

EGFR

  

up

down

Egf receptor

ArfGAP

GAP69C

 

down

up

down

GTPase-activating protein 69C

VPS25

VPS25

   

down

Vacuolar protein sorting 25

beta-arrestin

krz

  

up

down

kurtz, β-arrestin

E3 ligase

Traf6

up

down

 

down

TNF-receptor-associated factor 6

E3 ligase

elgi

up

down

  

early girl

GRK

GPCRK 1

up

down

  

G protein-coupled receptor kinase 1

RTK

Ret

up

down

  

Ret oncogene

Cbl; E3 ligase

Cbl

up

up

up

down

ubiquitin mediated proteolysis

VPS37

CG11155

up

down

down

 

ESCRT-I complex subunit VPS37

PIP5K

CG17471

up

down

down

up

1-phosphatidylinositol-4-phosphate 5-kinase

CHMP4

shrb

down

up

down

up

shrub, charged multivesicular protein

Hsc70

Hspc 2

 

up

down

up

Heat shock protein cognate 2

FIP

nuf

down

up

down

up

nuclear fallout, Rab11 interacting protein

Epsin

lfs

 

up

down

up

liquid facets

endophilin

endoB

  

down

up

endophilin B

CHMP6

Vps20

down

up

  

vacuolar protein sorting 20

Clathrin

Chc

down

up

  

Clathrin heavy chain

TSG101

TSG101

down

up

  

tumor suppressor protein 101

STAM

Stam

   

up

signal transducing adaptor molecule

VPS28

Vps28

 

up

 

up

vacuolar protein sorting 28

PAR6

par-6

 

up

up

up

partitioning defective 6

Hsc70

Hspc 1

  

up

up

Heat shock protein cognate 1

Hsc70

Hsp 68

up

up

  

Heat shock protein 68

RTK

Pvr

up

up

  

PDGF- and VEGF-receptor related

ARFGTPase

CG7435

up

up

  

ADP ribosylation factor 84F

ArfGAP

CG30372

up

up

  

SH3 domain, ANK repeat and PH domain

ArfGAP

cenB1A

up

up

  

centaurin beta 1A

VPS4

Vps4

up

up

  

vacuolar protein sorting 4

CHMP2

CG14542

up

up

  

charged multivesicular body protein 2A

CHMP2

CG4618

up

up

  

charged multivesicular body protein 2B

MVB12

CG7192

up

up

  

ESCRT-I complex subunit MVB12

Hrs

Hrs

up

up

  

HGF regulated tyrosine kinase substrate

PAR3

baz

up

up

  

bazooka, partitioning defective 3

VTA1

CG7967

up

up

  

vacuolar protein sorting-associated protein

CHMP5

CG6259

 

up

  

charged multivesicular body protein 5

CHMP1

CG4108

 

up

  

charged multivesicular body protein 1

ArfGAP

cenG1A

 

up

  

centaurin gamma 1A

Rab11

Rab 11

 

up

  

Rab-protein 11

  1. Significant alterations in gene expression from wild type are shown by word code; "up" represents upregulation and "down" downregulation of gene expression. Gene name stands for the particular homologue gene name in Drosophila. Notice that the same KEGG identifier can lead to several different genes in Drosophila. The according coloured scheme for endocytosis KEGG pathway is presented in Figure 4.
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BMC Genomics

ISSN: 1471-2164

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