Enhancer and promoter-like candidates co-ordinately regulate gene expression. Boxplots of ES cell gene expression of the genes closest to various subsets of Enh and PrL candidates. Enh&PrL denotes genes with at least one of both Enh and PrL closest to their TSSs; PrL set denotes genes with PrL but not Enh closest to them and vice versa for Enh set; None set denotes genes without any Enh and PrL closest to them. The numbers in brackets below each set show the counts of genes within the category. The y-axis denotes gene expression represented by RPKM plotted on a log scale. Distributions of gene expression are all significantly higher compared to sets on their right (*** p-values <10−7).