|
Motif
|
Raw score
|
Max Enh prob
|
RPKM
|
PSSM
|
|---|
|
SP1
|
339
|
0.8099
|
33.5
|
[12]
|
|
KLF4#
|
154
|
†
|
126.07
|
[12]
|
|
SOX2#
|
140
|
1
|
942.79
|
[12]
|
|
POU5F1#
|
128
|
0.9487
|
1318.38
|
[12]
|
|
SOX4
|
89.6
|
--
|
37.06
|
[70]
|
|
SOX11
|
86.5
|
0.6035
|
2.86
|
[70]
|
|
ESRRB#
|
72.6
|
0.9999
|
162.78
|
[12]
|
|
KLF7
|
61
|
--
|
4.94
|
[70]
|
|
ESRRA
|
37
|
--
|
4.02
|
[70]
|
|
NR4A2
|
33.7
|
--
|
0.03
|
[12]
|
|
STAT3#
|
31.6
|
0.5795
|
29.92
|
[12]
|
|
ZIC2
|
31.3
|
0.4291
|
13.76
|
[70]
|
|
ZIC1
|
29.6
|
0.5901
|
0.06
|
[70]
|
|
RARA
|
28.3
|
0.5909
|
30.28
|
[70]
|
|
ASCL2
|
25.1
|
--
|
0.72
|
[70]
|
|
NR2F2
|
19.9
|
0.5537
|
0.07
|
[70]
|
|
ZIC3
|
14
|
0.9550
|
15.27
|
[70]
|
|
RORA
|
7
|
0.5016
|
0.13
|
[12]
|
|
NFE2L2 (NRF2)
|
6.28
|
0.5947
|
68.09
|
[12]
|
|
RXR::RAR_DR5
|
4.89
|
--
|
5.34 (Rxra) 17.55 (Rxrb) 30.28 (Rara)
|
[12]
|
|
TEAD1
|
3.91
|
0.8987
|
66.24
|
[12]
|
- The motifs of the listed TFs are significantly enriched with p < 0.01 in putative enhancer regions compared to random sequences drawn from PrL set, chr19 and promoter 5 kb regions using the Clover algorithm [27] with TF binding matrices reported in PSSM column Raw scores from Clover algorithm are reported. “Max Enh prob” column lists the maximum probabilities of enhancers if at least one Enh is closest to the TSS of the corresponding gene. Probabilities greater than 0.8 are underlined. RPKM column reports the absolute gene expression of the TF in mouse ES cells. † Several putative enhancer located 50 kb downstream of Klf4 are categorized to another non protein-coding transcript. ‘#’ sign denotes the TFs with ChIP-Seq datasets in mouse ES cells.
