MicroRNA modulate alveolar epithelial response to cyclic stretch

BMC Genomics

Table 1 Five largest up- and down-regulated miRNAs

miRNA probe	Fold change	Probable genes^a predicted by both algorithms
miR-32*^b	2.9	—
miR-466c-5p	2.8	22
miR-466d-5p	2.8	30
miR-466c	2.6	4
miR-466b	2.6	7
miR-466f-3p^c	2.4	38
miR-375	−1.7	13
miR-378	−1.6	18
miR-347	−1.6	23
miR-15b	−1.6	21
miR-154	−1.5	16

^a Probable gene targets are candidates from a parallel mRNA expression array differentially expressed with cyclic stretch of 25% ΔSA at 6 hours, and predicted by both MicroCosm and TargetScan algorithms; see text for details.
^b The majority of miRNAs with the “*” designation are considered passenger transcripts of a precursor miRNA, and do not have calculated TargetScan targets.
^c MiR-466f-3p is the 7^th highest up-regulated miRNA, and was chosen for subsequent validation studies; it is included here for reference.

ISSN: 1471-2164