Figure 3

Gene markers of early antiviral response. Heat map of 20 selected genes with expression profile showing upregulation at the early stage and gradually decreased expression during mid and late stages of infection (complete data in Additional file 3). Left columns show the median log₂ expression ratios of genes in the different stages and responder groups (“E” = early, “M:HR” = mid stage HR, “M:LR” = mid stage LR, “L:HR” = late stage HR, “L:LR” = late stage LR). Graded levels from white to red and blue indicate respectively upregulation and downregulation, according to the color scale (row “L”). Significant differences in log₂–ER between control and infected samples (t-test, p < 0.05) are shown in bold. Column “cat” indicates the category of gene annotation according to [10]: V- early antiviral and IFN response, P- MHC antigen presentation.