Figure 7

Evolutionary relationships of HOX A11AS orthologues. The genes flanking HOXA11AS, HOXA11 and HOXA13, in the human (chr7:27,220,777–27,239,725; http://genome.ucsc.edu) are shown along with their conservation score (phylop). HOXA11AS gene structure consists of two exons in eutherian mammals except mouse, but one exon in tammar (lower left), based on predicted with RNA secondary structure and sequence alignment. Phylogenetic trees showing exon2 is highly conserved in eutherian mammals whilst exon1 is more divergent with the full predicted exon 1 sequence, consistent with the mammalian consensus sequences in the top panel (lower right).