From: On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer
Gene(s) | Locus_tag(s) | Comments | Reference |
---|---|---|---|
selA | MMAR_5190 | selenocysteine synthase, required for the synthesis of proteins containing selenocysteine. | [1] |
 | MMAR_5194 MMAR_5195 | Formate dehydrogenase alpha and beta subunits, selenocysteine-containing. Likely role in anaerobic growth. | [1] |
 | MMAR_2615 | Anaerobic dehydrogenase (putative nitrate reductase), possible role in anaerobic growth. |  |
lgt | MMAR_2416 | Lgt acylates prolipoproteins, thus key role in lipoprotein synthesis. Lgt mutant of S. aureus is less immunogenic. | |
plcB_2, | MMAR_1485 | M. marinum has six plc genes. Four of these are absent in all M. ulcerans. Phospholipase C enzymes can cause direct or indirect enzymatic hydrolysis of host cell membrane phospholipids and appear important for mycobacterial intracellular survival. | [48] |
plcB_5, | MMAR_3656 | ||
plcB_6, | MMAR_4722 | ||
plcB_3 | MMAR_0284 | ||
cstA | MMAR_1616 | Carbon starvation protein, CstA. In E. coli, cstA encodes a peptide transporter and is induced by carbon starvation. Maybe part of a redundant stress response system in M. ulcerans. | [49] |
cueO | MMAR_1618 | Multicopper oxidases protect against oxidative stress. This enzyme has functions in tolerance to copper, and iron and manganese oxidation in a range of bacteria. It catalyses the oxidation of cuprous copper, ferrous iron and diphenolic compounds. In Salmonella, a cueO deletion mutant is less virulent in mouse model. Divergent transcriptional arrangement with cstA. | [50] |
idsB1, | MMAR_3212 | Catalyzes the trans-addition of three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids. Impact here of diverting all isoprenoid biosynthesis to the non-mevalonate pathway is not known. Possibly more favourable energetically if spending cellular resources on mycolactone synthesis. | [1] |
idsB2, | MAR_3219 | ||
idsA1 | MMAR_5095 |