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Figure 2 | BMC Genomics

Figure 2

From: Visualizing spatiotemporal dynamics of apoptosis after G1 arrest by human T cell leukemia virus type 1 Tax and insights into gene expression changes using microarray-based gene expression analysis

Figure 2

Expression profile of genes involved in cell cycle regulation and apoptosis that were altered following the induction of Tax protein. Heat maps showing the hierarchical clustering of genes involved in cell cycle regulation (A) and apoptosis (C) are shown for Tax-expressing cells. The color scheme indicates the fold change in gene expression, with upregulated genes shown in orange/red and downregulated genes shown in blue (with respect to baseline levels under control conditions (yellow)). qRT-PCR validation of the upregulated genes associated with cell cycle regulation (B) and apoptosis (D). RNA from Tax-expressing cells and control cells was used to validate the microarray data. The bars indicate the fold change in gene expression following Tax expression. Data were normalized to GAPDH mRNA. The results represent the mean of two samples from one experiment

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BMC Genomics

ISSN: 1471-2164

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