Celiac disease T-cell epitopes from gamma-gliadins: immunoreactivity depends on the genome of origin, transcript frequency, and flanking protein variation

Table 2 CD-epitope cores derived from γ-gliadins

CD-epitope cores (9-mer binding cores) derived from γ-gliadins. The targets for tTG deamidation are depicted in bold underlined. ²Sjöström et al. [17], ³Qiao et al.[7], ⁴Vader et al.[22], ⁵Arentz-Hansen et al [19], ⁶Stepniak et al.[21]. *deamidation dependent epitope, Q QPQ QPF/YPQ, deamidation at position 4 is HLA-DQ2 restricted and deamidation at positions 1 and 9, Q QPQ QP(F/Y)PQ is HLA-DQ8 [8]; the same counts for DQ2-γ-VI (Q QPFPQ QPQ), in case of deamidation at P1 and P9 this epitope is HLA-DQ8 restricted [9]. ** Nomenclature and listing of celiac disease relevant gluten T-cell epitopes (Sollid et al. [55]).

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