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Table 3 The downward effect of JTX on the gene expression in the large intestine in IQI GF mice

From: Microarray analysis on germfree mice elucidates the primary target of a traditional Japanese medicine juzentaihoto: acceleration of IFN-α response via affecting the ISGF3-IRF7 signaling cascade

GFLI-down     
Probe Set ID Gene Name Gene Symbol Entre ID Fold Change p-value
103842_at DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked Ddx3y 26900 0.02 0.004
103674_f_at eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked Eif2s3y 26908 0.07 0.008
103639_at interferon-induced protein with tetratricopeptide repeats 2 Ifit2 15958 0.09 0.015
104750_at interferon gamma inducible protein 47 Ifi47 15953 0.12 0.002
100981_at interferon-induced protein with tetratricopeptide repeats 1 Ifit1 15957 0.18 0.021
104177_at radical S-adenosyl methionine domain containing 2 Rsad2 58185 0.20 0.012
102906_at T-cell specific GTPase Tgtp 21822 0.24 0.034
96764_at interferon inducible GTPase 1 Iigp1 60440 0.27 0.001
103202_at guanylate nucleotide binding protein 4 Gbp4 55932 0.29 0.045
160933_at interferon gamma induced GTPase Igtp 16145 0.30 0.004
98410_at interferon inducible GTPase 2 Iigp2 54396 0.36 0.014
104669_at interferon regulatory factor 7 Irf7 54123 0.38 0.034
103335_at lectin, galactose binding, soluble 9 Lgals9 16859 0.38 0.039
100030_at uridine phosphorylase 1 Upp1 22271 0.40 0.015
103634_at interferon dependent positive acting transcription factor 3 gamma Isgf3g 16391 0.44 0.040
92715_at ubiquitin D Ubd 24108 0.44 0.011
93085_at proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) Psmb9 16912 0.47 0.036
102791_at proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) Psmb8 16913 0.49 0.014
103446_at interferon induced with helicase C domain 1 Ifih1 71586 0.50 0.038
101465_at Signal transducer and activator of transcription 1 Stat1 20846 0.51 0.026
103035_at transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Tap1 21354 0.54 0.035
97950_at xanthine dehydrogenase Xdh 22436 0.54 0.010
104597_at guanylate nucleotide binding protein 2 Gbp2 14469 0.56 0.025
97507_at lectin, galactoside-binding, soluble, 3 binding protein Lgals3bp 19039 0.60 0.047
102200_at aquaporin 8 Aqp8 11833 0.60 0.019
102873_at transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) Tap2 21355 0.60 0.015
103254_at TRAF type zinc finger domain containing 1 Trafd1 231712 0.60 0.011
103892_r_at elongation factor RNA polymerase II 2 Ell2 192657 0.62 0.039
99475_at suppressor of cytokine signaling 2 Socs2 216233 0.66 0.024
92672_at GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus Gnas 14683 0.67 0.010
98472_at histocompatibility 2, T region locus 23///RIKEN cDNA C920025E04 gene H2-T23 15040 0.67 0.007
  1. The genes whose change was < 0.67 fold and with p < 0.1 (n = 3, Welch's t test) were the listed sorted by fold-change. Twenty four immunoglobulin genes and 14 unidentified probe sets were omitted from the lists. The genes appeared commonly in both Tables 3 and 4 were in bold letters. The genes appeared commonly in Tables 1 and 3 were underlined.