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Table 3 The downward effect of JTX on the gene expression in the large intestine in IQI GF mice

From: Microarray analysis on germfree mice elucidates the primary target of a traditional Japanese medicine juzentaihoto: acceleration of IFN-α response via affecting the ISGF3-IRF7 signaling cascade

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Probe Set ID

Gene Name

Gene Symbol

Entre ID

Fold Change

p-value

103842_at

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked

Ddx3y

26900

0.02

0.004

103674_f_at

eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked

Eif2s3y

26908

0.07

0.008

103639_at

interferon-induced protein with tetratricopeptide repeats 2

Ifit2

15958

0.09

0.015

104750_at

interferon gamma inducible protein 47

Ifi47

15953

0.12

0.002

100981_at

interferon-induced protein with tetratricopeptide repeats 1

Ifit1

15957

0.18

0.021

104177_at

radical S-adenosyl methionine domain containing 2

Rsad2

58185

0.20

0.012

102906_at

T-cell specific GTPase

Tgtp

21822

0.24

0.034

96764_at

interferon inducible GTPase 1

Iigp1

60440

0.27

0.001

103202_at

guanylate nucleotide binding protein 4

Gbp4

55932

0.29

0.045

160933_at

interferon gamma induced GTPase

Igtp

16145

0.30

0.004

98410_at

interferon inducible GTPase 2

Iigp2

54396

0.36

0.014

104669_at

interferon regulatory factor 7

Irf7

54123

0.38

0.034

103335_at

lectin, galactose binding, soluble 9

Lgals9

16859

0.38

0.039

100030_at

uridine phosphorylase 1

Upp1

22271

0.40

0.015

103634_at

interferon dependent positive acting transcription factor 3 gamma

Isgf3g

16391

0.44

0.040

92715_at

ubiquitin D

Ubd

24108

0.44

0.011

93085_at

proteosome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)

Psmb9

16912

0.47

0.036

102791_at

proteosome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)

Psmb8

16913

0.49

0.014

103446_at

interferon induced with helicase C domain 1

Ifih1

71586

0.50

0.038

101465_at

Signal transducer and activator of transcription 1

Stat1

20846

0.51

0.026

103035_at

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Tap1

21354

0.54

0.035

97950_at

xanthine dehydrogenase

Xdh

22436

0.54

0.010

104597_at

guanylate nucleotide binding protein 2

Gbp2

14469

0.56

0.025

97507_at

lectin, galactoside-binding, soluble, 3 binding protein

Lgals3bp

19039

0.60

0.047

102200_at

aquaporin 8

Aqp8

11833

0.60

0.019

102873_at

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Tap2

21355

0.60

0.015

103254_at

TRAF type zinc finger domain containing 1

Trafd1

231712

0.60

0.011

103892_r_at

elongation factor RNA polymerase II 2

Ell2

192657

0.62

0.039

99475_at

suppressor of cytokine signaling 2

Socs2

216233

0.66

0.024

92672_at

GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus

Gnas

14683

0.67

0.010

98472_at

histocompatibility 2, T region locus 23///RIKEN cDNA C920025E04 gene

H2-T23

15040

0.67

0.007

  1. The genes whose change was < 0.67 fold and with p < 0.1 (n = 3, Welch's t test) were the listed sorted by fold-change. Twenty four immunoglobulin genes and 14 unidentified probe sets were omitted from the lists. The genes appeared commonly in both Tables 3 and 4 were in bold letters. The genes appeared commonly in Tables 1 and 3 were underlined.