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Table 6 Putative promoter modules affected by JTX treatment

From: Microarray analysis on germfree mice elucidates the primary target of a traditional Japanese medicine juzentaihoto: acceleration of IFN-α response via affecting the ISGF3-IRF7 signaling cascade

module # module matches (# sequences) Appearance ratio (# matches/# sequences) Significance
  SPFLI-up (26) BALB -down (26) GFLI -down (45) GFSI down (55) All promoters (51460) SPFLI-up/BALB-down/GFLI-down/GFSI-down* All annotated promoters  
V$IRFF-V$IRFF 31 33 55 67 19374 1.225 ± 0.032 0.376 < 0.0001
V$IRFF-V$MYT1 14 12 24 30 13423 0.520 ± 0.039 0.261 0.0009
V$CREB-V$GCMF 4 6 10 14 4675 0.215 ± 0.043 0.091 0.0104
V$ETSF-V$DEAF 3 8 17 17 6540 0.277 ± 0.113 0.127 0.0706
  1. * The values represent the mean ± S.D. of the appearance ration of these 4 groups.
  2. Definition of promoter modules**
  3. V$IRFF: interferon regulatory fatctors,
  4. V$MYT1: MYT1 C2HC zinc finger protein,
  5. V$CREB: cAMP-responsive element binding proteins,
  6. V$GCMF: Chorion-specific transcription factors with a GCM DNA binding domain,
  7. V$ETSF: Ets1 factors,
  8. V$DEAF: Homolog to deformed epidermal autoregulatory factor-1 from D. melanogaster
  9. **See Website of Genomatix Inc http://www.genomatix.de/ for further information.