Figure 1
From: Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens
Schematic illustration of the signaling pathway of GHR regulated by let-7b. miRNA let-7b inhibits the expression of GHR and regulates SOCS3 . SOCS3 regulates the growth and development of chickens through three signaling pathways: inhibiting the phosphorylation of tyrosine in IRS1; inhibiting LEPR; and inhibiting JAK. IRS1, LEPR and JAK are involved in growth, fat synthesis, and cell proliferation.