Differential microRNA response to a high-cholesterol, high-fat diet in livers of low and high LDL-C baboons

BMC Genomics

Table 7 Expression profiles of miRNAs associated with metabolic disorder risk factors

miRNA	Low LDL-C (Chow vs HCHF)	p value	High LDL-C (Chow vs HCHF)	p value	Biological processes associated with disease risk factors	References
miR-29b	Down	0.018	Down	0.01	Demethylation of MMP-2/MMP-9 genes involved in cell migration in aorta	[43]
miR-26a-1*	Down	0.007	Down	0.32	Regulator of vascular smooth muscle cell function	[44]
miR-221	Down	0.45	Down	0.02	Angiogenesis in hypertrophy	[41]
miR-222	Down	0.39	Down	0.01	Angiogenesis in hypertrophy	[41]
miR-222*	Up	0.98	Down	0.66
miR-143	Down	0.67	Down	0.17	Proliferation of vascular smooth muscle cells	[45]
miR-122	Up	0.69	Down	0.19	Lipid metabolism	[30, 32]
miR-122*	Down	0.43	Down	0.38
miR-335	Up	0.48	-	-	Lipid metabolism	[31]
miR-335*	Down	0.31	Down	0.29
miR-21	Down	0.63	Down	0.62	Cell proliferation in carotid artery	[46]
miR-1	Down	0.42	Down	0.35	Repolarization and diastolic activity	[47]
miR-146a,b	Down	0.12	Down	0.36	LDL-C oxidization accumulation in monocytes	[23][24]
miR-155	Down	0.17	Down	0.43	Oxidized LDL-C accumulation in monocytes	[24]
miR-130b	Down	0.98	Down	0.59	Arteriosclerosis obliterans	[48]
miR10a	Down	0.39	Down	0.47	Regulation of pro-inflammation in aorta	[49]

- Indicates that the miRNA was not detected. miRNA stars (*) are presented for comparison with mature miRNAs.

ISSN: 1471-2164