Table 4 Annotation clusters affected by lead in individuals with high blood lead levels

GOTERM_BP_FAT

GO:0010941 ~ regulation of cell death

2.05E-05

0.04

GOTERM_BP_FAT

GO:0042981 ~ regulation of apoptosis

2.21E-05

0.04

GOTERM_BP_FAT

GO:0043067 ~ regulation of programmed cell death

3.15E-05

0.06

Annotation Cluster 2

Enrichment Score: 4.4

Category

Term

P-value

FDR

GOTERM_BP_FAT

GO:0010629 ~ negative regulation of gene expression

1.24E-05

0.02

GOTERM_BP_FAT

GO:0016481 ~ negative regulation of transcription

1.33E-05

0.02

GOTERM_BP_FAT

GO:0010558 ~ negative regulation of macromolecule biosynthetic process

1.97E-05

0.04

GOTERM_BP_FAT

GO:0031327 ~ negative regulation of cellular biosynthetic process

2.22E-05

0.04

GOTERM_BP_FAT

GO:0009890 ~ negative regulation of biosynthetic process

2.23E-05

0.04

GOTERM_BP_FAT

GO:0045934 ~ negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

7.26E-05

0.13

GOTERM_BP_FAT

GO:0051172 ~ negative regulation of nitrogen compound metabolic process

1.05E-04

0.19

GOTERM_BP_FAT

GO:0010605 ~ negative regulation of macromolecule metabolic process

6.31E-04

1.14

Annotation Cluster 3

Enrichment Score: 4.0

Category

Term

P-value

FDR

GOTERM_BP_FAT

GO:0043068 ~ positive regulation of programmed cell death

9.01E-05

0.16

GOTERM_BP_FAT

GO:0010942 ~ positive regulation of cell death

1.00E-04

0.18

GOTERM_BP_FAT

GO:0043065 ~ positive regulation of apoptosis

1.47E-04

0.27

Annotation Cluster 4

Enrichment Score: 3.8

Category

Term

P-value

FDR

GOTERM_BP_FAT

GO:0016481 ~ negative regulation of transcription

1.33E-05

0.02

GOTERM_BP_FAT

GO:0045892 ~ negative regulation of transcription, DNA-dependent

4.50E-04

0.81

GOTERM_BP_FAT

GO:0051253 ~ negative regulation of RNA metabolic process

6.25E-04

1.13