Pleiotropic functions of catabolite control protein CcpA in Butanol-producing Clostridium acetobutylicum

BMC Genomics

Table 1 Numbers of genes (with known or predicted functions) that exhibited significant up- or down-regulation after inactivation of ccpA

Function category	No. of genes affected by *ccpA* inactivation
	M (Middle exponential phase)		L (Late exponential phase)		T (Transition phase)		S (Stationary phase)
	Up-regulation	Down-regulation	Up-regulation	Down-regulation	Up-regulation	Down-regulation	Up-regulation	Down-regulation
G. Carbohydrate transport and metabolism	96	9	96	10	84	10	103	9
E. Amino acid transport and metabolism	38	28	9	38	31	52	42	18
H. Coenzyme transport and metabolism	21	12	10	11	16	9	22	22
R. General function prediction only	20	19	20	24	24	23	24	36
K. Transcription	19	13	20	13	22	13	25	22
F. Nucleotide transport and metabolism	14	4	14	1	13	3	11	7
T. Signal transduction mechanisms	11	15	12	7	11	19	19	10
C. Energy production and conversion	10	22	5	15	9	11	16	12
I. Lipid transport and metabolism	9	3	9	3	9	2	11	14
O. Posttranslational modification, protein turnover, chaperones	9	10	2	17	5	16	7	8
N. Cell mobility	8	12	11	4	7	12	14	3
M. Cell wall/membrane biogenesis	8	16	10	10	9	20	13	35
P. Inorganic ion transport and metabolism	8	22	5	25	11	17	25	18
J. Translation	6	5	10	3	5	3	6	38
L. Replication, recombination and repair	5	2	9	1	3	0	4	12
Q. Secondary metabolites biosynthesis, transport and catabolism	4	1	3	1	3	1	3	6
V. Defense mechanisms	2	3	2	1	4	2	5	7
D. Cell cycle control, mitosis and meiosis	1	1	2	1	1	1	2	4
U. Intracellular trafficking and secretion	1	0	1	0	2	0	4	4
S. Function unknown	11	22	12	21	13	20	18	37
Not in COGs	93	57	115	46	75	50	124	149
Total	370	266	352	244	330	278	465	471

ISSN: 1471-2164