Figure 7
Genes dependent on RosR and responsive to ROS (H 2 O 2 and PQ) are enriched for functions in protein and DNA repair. (A) Predicted functions of genes differentially expressed in response to H2O2 according to archaeal Clusters of Orthologous Groups (arCOG) categories [48]. Category annotations are listed in on the Y-axis. Black bars represent the number of genes in each category dependent upon RosR for their differential expression (Figure 5A-G), whereas grey bars enumerate genes in each category that are differentially expressed in response to H2O2 but not affected by the ΔrosR mutation (i.e. “RosR-independent”, Figure 5H and J). (B) Predicted functions of genes differentially expressed in response to paraquat (PQ) according to arCOG. Colors and category annotations are as in (A). Asterisks denote significant overrepresentation of a functional category with p < 0.05. Plus signs (+) indicate enrichment p < 0.2. Details of gene annotations, membership in each arCOG category, and p-values for enrichment for all categories are listed in Additional file 4: Table S2 for H2O2 data and Additional file 5: Table S3 for PQ data.