Signature enrichment analysis of drug-modulated direct activation (top panel) and repression targets (bottom panel) of AR. Shown are enriched gene signatures, with size of each node proportional to number of genes in the signature and width of each line proportional to statistical significance of the overlap between the signatures at the two ends. The signatures were colored by related biological concepts. Direct_AR-activation/Compound30-down_regulated targets refer to genes whose associated AR binding are impacted as well as mRNA level are significantly down-regulated upon Compound 30 treatment. Direct_AR-repression/Compound30-up_regulated targets refer to genes whose associated AR binding are impacted as well as mRNA level are significantly up-regulated upon Compound 30 treatment.