Table 5 Gene set enrichment analysis (GSEA) of classifiers on their original gene expression profiles (GEPs) for training
| Chemical | Brain GEP (F-ratio) | Brain classifiers enriched on brain GEP (FDR) | Ovary GEP (F-ratio) | Ovary classifiers enriched on ovary GEP (FDR) |
|---|---|---|---|---|
| Fadrozole (FAD) | FAD-brain (3.41) | No enrichment | FAD-ovary (2.01)a | PRO-ovary (0.005) |
| KET-ovary (0.006) | ||||
| FLU-ovary (0.01) | ||||
| 17α-ethynyl estradiol (EE2) | EE2-brain (5.96) | EE2-brain (0.028) | EE2-ovary (22.4)b | KET-ovary (0.002) |
| PRO-ovary (0.004) | ||||
| FLU-ovary (0.023) | ||||
| Muscimol (MUS) | MUS-brain (6.42) | MUS-brain (0.0) | MUS-ovary (42.62)b | FIP-ovary (0.027) |
| KET-ovary (0.035) | ||||
| PRO-ovary (0.052) | ||||
| FLU-ovary (0.077) | ||||
| Fipronil (FIP) | FIP-brain (6.78) | FIP-brain (0.002); MUS-brain (0.012) | FIP-ovary (10.23) | FIP-ovary (0.006); |
| PRO-ovary (0.0) | ||||
| KET-ovary (0.0) | ||||
| Flutamide (FLU) | NA | FLU-ovary (67.23) | KET-ovary (0.002) | |
| PRO-ovary (0.006) | ||||
| FLU-ovary (0.007) | ||||
| Ketoconazole (KET) | KET-brain (9.17) |
KET-brain (0.006); MUS-brain (0.008) | KET-ovary (4.85) | KET-ovary (0.0) |
| PRO-ovary (0.008) | ||||
| FLU-ovary (0.18) | ||||
| Prochloraz (PRO) | PRO-brain (19.42) | PRO-brain (0.0) | PRO-ovary (14.48) | PRO-ovary (0.0) |
| KET-ovary (0.009) | ||||
| FLU-ovary (0.008) | ||||
| 17β-trenbolone (TRE) | TRE-brain (22.94)b | No enrichment | TRE-ovary (3.28)a | KET-ovary (0.1) |
| PRO-ovary (0.234); | ||||
| FIP-ovary (0.236) | ||||
| Trilostane (TRI) | NA | TRI-ovary (11.16)b | PRO-ovary (0.121) | |
| Vinclozolin (VIN) | NA | VIN-ovary (6.09) | VIN-ovary (0.024); | |
| KET-ovary (0.0) | ||||
| PRO-ovary (0.107) | ||||
| FLU-ovary (0.106) | ||||
| F-ratio mean = 10.59 | F-ratio mean = 18.44 |